Premarin Vaginal Cream 0.625 mg (14gm)

About Premarin Vaginal Cream 0.625 mg (14gm)

Premarin Vaginal Cream is primarily used to treat the vaginal symptoms of menopause problems that arise in women, like itching and burning.

The salt present in Premarin Vaginal Cream is Conjugated Estrogen.

This cream is used when the amount of Estrogen the body makes decreases.

Usage

Premarin Vaginal Cream is a form of Hormone Replacement Therapy.

This cream is also used to treat problems associated with breast cancer.

Hormone Replacement Therapy

This form of therapy treats symptoms associated with menopause, such as dryness in the vagina, night sweats, less desire to have sex, and mood swings.

Hormone Replacement Therapy works by replacing the Estrogen in the body. The body stops making Estrogen after menopause, so Premarin Vaginal cream treats the condition.

Remember that if you want to treat only the vaginal symptoms of menopause, try to use medications that are applied externally.

Working

The Premarin Vaginal Cream replaces the Estrogen lost in the body due to menopause. 

Loss of Estrogen in the body happens as a woman hits menopause and the body stops making Estrogen. 

How to use it?

Here is how you should use the Premerin Vaginal Cream:

You should use the Premarin Vaginal Cream as directed by the doctor

According to the directions, fill the applicator with medicine and insert it deep into the vagina. It would help if you pressed the plunger to release the medication

For cleaning the applicator, you should use warm water with soap to clean the applicator

Missed Dose

If you miss your dose, use only what is necessary for the subsequent amount. Taking an extra dose to compensate for the missed one may harm you.

Instead, use it when you remember if it is not time for your next dose yet. You can skip the previous one if it is already time for your next dose.

Overdose

You should consult your doctor if there is an overdose of the cream.

Strengths

Premarin Vaginal Cream is also available in the strength of 0.3 mg, 0.45 mg, 0.9 mg, and 1.25 mg.

Side effects

The side effects of this medication include breast tenderness, bloating, weight change, nausea/ vomiting, and headache.

You should approach your doctor right away if you experience any side effects, including:

• Vaginal bleeding, such as spotting or recurrent bleeding
• Severe abdominal/ stomach pain 
• Mood changes or mental problems like depression or memory problems
• Swelling feet, ankles, or hands
• Yellowing skin or eyes
• Dark urine
• Increased thirst or urination

Keep in mind that there might be some side effects. 

However, these side effects fade away with time, and you can treat them if you follow your doctor's instructions.

Interactions

Although Primarin Vaginal Cream is safe, sometimes there might be some cases where it interacts with medicines or diseases to show side effects.

Drug Interactions

The following list contains the possible drugs that can interact with Premarin Vaginal Cream to produce side effects. List all medicines you consume and show them to your doctor.

It will help if you don't start or stop a medication without prior approval from your doctor.

• Fulvestrant
• Tamoxifen
• Aromatase inhibitors (such as anastrozole, exemestane, letrozole) 
• Tranexamic acid
• Toremifene
• Ospemifene 
• Raloxifene

Disease Interactions

You should not use Premarin Vaginal Cream if you have:

• Undiagnosed vaginal bleeding
• Bleeding disorder
• Liver disease
• Stroke
• Heart attack
• Breast cancer
• Cancer of the cervix/ uterus or vagina

Food Interactions

You are recommended not to consume grapefruit juice while using Premarin Vaginal Cream.

Precautions

These are the precautions you need to be careful of while using the Premarin Vaginal Cream:

• Tell your doctor if you might be allergic to this medication or have any other allergies
• You should tell your doctor your medical history; especially if you have cancer, blood clot, heart disease, stroke, vaginal bleeding (of unknown causes), family medical history, hypothyroidism, seizure, asthma, or hormonal problems
• Do not use tobacco or smoke
• Please don't stay in the sun for too long, as it may cause parts of your skin to become dark
• Do tell the doctor if you will be confined to bed for a long time or if you have major surgery soon, as it increases the chances of your blood clotting

Storage

You should store this cream at 20-25°C or 68-77°F.

Frequently Asked Questions

How long should a woman use Premarin cream?

For painful intercourse, 0.5g of Premarin Cream is used twice a week or according to a cyclic period of 21 days of Hormone Replacement Therapy. 

Seven days off treatment is then given. It would be best if you used the Premarin Cream as directed by your doctor. 

What happens when you stop using Premarin cream?

Estrogen withdrawal is experienced if you suddenly stop using Premarin Cream, due to which night sweats and hot flashes may occur. 

You can reduce the withdrawal symptoms by slowly decreasing the dose of the cream used over time.

Does Premarin make you gain weight?

The right amount of Estrogen in the body can help the body carry out reproductive functions. 

However, too much or too little Estrogen in the body can result in weight gain. 

Large amounts of Estrogen are found in women in their first half of pregnancy and overweight women.