Find Out: What Causes Endometriosis? 

Rishabh Mehta
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Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
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what causes endometriosis

Endometriosis is a complex and often painful condition that affects millions of women worldwide. 

This disorder occurs when tissue similar to the lining of the uterus, known as endometrium, grows outside the uterus. 

While Endometriosis can significantly impact a woman’s quality of life, the exact causes remain unknown. 

In this article, we will explore the potential causes of Endometriosis, the associated risk factors, and whether Polycystic Ovary Syndrome (PCOS) plays a role in its development.

Causes of Endometriosis

The exact cause of Endometriosis is unclear, but there are various theories trying to explain how it develops.

One leading hypothesis is retrograde menstruation.

It is a condition where menstrual blood containing endometrial cells flows back through the fallopian tubes into the pelvic cavity instead of coming out through the vagina. 

These displaced cells then adhere to the pelvic organs and surfaces, leading to the formation of endometrial lesions.

Another theory suggests that Endometriosis may result from genetic factors. 

Research indicates that women with a family history of Endometriosis are at a higher risk of developing the condition themselves.

Women with a family history of endometriosis have a much higher chance, up to 10 times more, of developing the condition themselves. 

Genetic predisposition may influence the immune system’s response to hormonal changes, making some women more susceptible to the growth of endometrial tissue outside the uterus.

Endometriosis has been found in some rare cases to affect certain animal species, including captive baboons and even pet dogs, providing intriguing insights into the potential environmental factors influencing the condition.

Risk factors

periods calendarSource: Firn
Menstrual calendar

Various factors contribute to the development of Endometriosis, revealing its complex nature.

Risk factors for endometriosis include:

  • Never giving birth
  • Early onset of menstruation
  • Late onset of Menopause
  • Short menstrual cycles (less than 27 days)
  • Prolonged and heavy menstrual periods (more than seven days)
  • Elevated levels of Estrogen or prolonged exposure to Estrogen in the body
  • Low body mass index (BMI)
  • Family history of Endometriosis, including relatives like mothers, aunts, or sisters

What causes Endometriosis to grow

The primary driver of Endometriosis growth is the hormonal fluctuations that occur during the menstrual cycle. 

Estrogen, a hormone responsible for the thickening of the uterine lining, stimulates the proliferation of endometrial cells. 

In women with Endometriosis, these cells also respond to Estrogen, leading to the growth of tissue outside the uterus.

In addition to hormonal influences, inflammation plays a crucial role in the progression of Endometriosis. 

The presence of endometrial lesions triggers an inflammatory response in the surrounding tissues, creating an environment conducive to the growth and survival of abnormal endometrial cells. 

This inflammatory process can cause pain, adhesions, and other complications associated with Endometriosis.

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Does PCOS cause Endometriosis

Polycystic Ovary Syndrome (PCOS)Source: natrot_from_natrot
Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome (PCOS) and Endometriosis are two distinct gynecological conditions, but they share some common symptoms and risk factors. 

PCOS is characterized by hormonal imbalances, Insulin resistance, and the presence of small cysts on the ovaries. 

While PCOS and Endometriosis can coexist in some women, having one condition does not directly cause the other.

However, women with PCOS may be at a slightly higher risk of developing endometrial cancer. 


Endometriosis, a perplexing and painful condition affecting millions, arises from tissue growing outside the uterus lining.

While theories like retrograde menstruation and genetic factors offer insights, the precise cause remains elusive. 

Various factors like age, menstrual patterns, and childbirth history reveal the complexity of Endometriosis risk.

Hormonal changes and inflammation fuel its growth. 

PCOS and Endometriosis have similarities, but a direct cause-effect relationship is not proven.

Continued research aims to unravel this intricate puzzle for improved understanding and management of Endometriosis.

Delayed diagnosis of Endometriosis can lead to complications, including infertility and chronic pain. Recognizing symptoms early and seeking medical attention is crucial for effective management and improved quality of life.

Frequently Asked Questions

What is the primary cause of Endometriosis?

Endometriosis does not have a singular cause, but factors such as genetic predisposition, hormonal imbalances, retrograde menstruation, immune system dysfunction, inflammatory processes, and environmental factors may contribute to its development.

How can genetics influence the risk of Endometriosis?

Individuals with a family history of Endometriosis are at a higher risk, suggesting a genetic predisposition. Specific genetic markers may contribute to an increased susceptibility to the condition.

What role do hormones play in Endometriosis?

Hormonal imbalances, particularly elevated Estrogen levels or an imbalance between Estrogen and Progesterone, create an environment conducive to the growth of endometrial tissue outside the uterus.

Is Endometriosis a hereditary condition?

While Endometriosis has a genetic component, it is not strictly hereditary. Having a family history increases the risk, but environmental and lifestyle factors also play a significant role.

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