Due to Premature Ejaculation, about 30% of men or Assigned Males at Birth (AMAB) cannot continue with sexual intercourse for their desired duration.

Doctors may treat this early ejaculation with antidepressants such as Zoloft, containing Sertraline. 

Therefore, those struggling with PE can use Sertraline for Premature Ejaculation after consulting their doctor.

This article delves in-depth to explore how effective is Sertraline for Premature Ejaculation, how it works, how to take the medicine, and so on.

How does Sertraline work for Premature Ejaculation

Sertraline, an SSRI (Selective Serotonin Reuptake Inhibitors) or antidepressant, treats mental health conditions like Depression, OCD, and PTSD.

Sertraline is used off-label for Premature Ejaculation.

Emerging clinical evidence indicates chronic and on-demand dosing of SSRIs has a beneficial effect on treating PE. 

The medicine increases Serotonin levels in the body.

Serotonin is a chemical in the brain that can affect sexual desire and thus plays a role in sexual function.

It is a neurotransmitter that is key in the ejaculatory response.

When Serotonin levels are high, it can decrease the ability of the brain to respond to sexual cues, which can lower sexual desire. 

This means that Serotonin can act as a brake on sexual desire. 

When there are low Serotonin levels in the brain, it may lead to Premature Ejaculation (PE). 

Increasing Serotonin levels in specific brain parts can delay ejaculation.

SSRIs, like Sertraline, work by preventing cells from reabsorbing Serotonin.

However, the effects of Serotonin on sexual function can depend on various factors.

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How is Sertraline used for Premature Ejaculation

Using Sertraline to treat Premature Ejaculation typically involves the following steps:

  • Doctor consultation: Before starting Sertraline Premature Ejaculation treatment, an individual should seek advice from a doctor. They will assess the condition and determine if Sertraline is appropriate for the individual
  • Getting a prescription: If deemed suitable, the healthcare professional will provide a prescription for Sertraline, specifying the dosage and duration
  • Followinginstructions: It is important to follow the prescribed dosage and follow the medical professional’s instructions carefully
  • Being patient: Results may not be immediate. It may take a few weeks of consistent use for Sertraline to show its full effects
  • Monitoring: After taking Sertraline for Premature Ejaculation, the user should keep in touch with their doctor to check their progress and discuss any concerns or side effects

How to take Sertraline for Premature Ejaculation

Various strengths of Sertraline, such as 25mg, 50mg, and 100mg dosages, are all suitable for helping PE.

There is no official recommended dose for Sertraline prescribed for PE, and doctors will usually prescribe up to 50 mg per day.

Even Sertraline 25 mg for Premature Ejaculation is an effective dosage for the condition. 

A medical expert may suggest starting with 25 mg and then increasing the dose as and when necessary.

People taking 50mg of Sertraline for treating PE have experienced improved ejaculation time.

Sertraline taken daily and taken 4 hours before sex (on-demand) both have been proven effective in increasing ejaculation time.

However, in people who took Serotonin daily, there was a significant increase in the ejaculation time and, therefore, the most effective.

But before taking Sertraline, one must consult a doctor for the ideal dosage.

Fact:
Sertraline is one of the most widely used antidepressants to manage and treat several mental health conditions.

Risks and considerations

For most people taking Sertraline for Premature Ejaculation, the medication is usually safe.

But people using Sertraline as needed for Premature Ejaculation should be aware of potential side effects and adverse interactions.

Sertraline for Premature Ejaculation side effects

Nausea – side effect
Nausea – side effect

Like most medicines, some users of Sertraline may be affected by its potential side effects.

Some common Sertraline for Premature Ejaculation side effects are:

  • Nausea
  • Headaches
  • Insomnia or feeling very sleepy
  • Diarrhea
  • Dry mouth
  • Dizziness or Drowsiness
  • Increased sweating
  • Loss of appetite or weight loss
  • Heartburn

Serious side effects of Sertraline happen rarely (in less than 1 in 100 people).

Some of these are:

  • Weight gain or weight loss without trying
  • Easy bleeding or bruising
  • Muscle cramps or weakness
  • Shaking (tremor)
  • Unusual weight loss

There are also rare side effects like vision problems, heart rhythm changes, severe allergic reactions, unusual bleeding or bruising, suicidal ideation, and Serotonin syndrome.

Warning:
Do not take Sertraline for Premature Ejaculation before talking to a doctor.
It may cause suicidal ideation in some people.

Interaction with other medications

Sertraline may interact with other medications and supplements.

Some of the medications that can react negatively on interaction with Sertraline are:

  • Bepridil
  • Bromopride
  • Cisapride
  • Clorgyline
  • Dronedarone
  • Eliglustat

Unsuitable health conditions

Sertraline might not suit everyone.

It may be unsuitable for people with certain medical conditions or those taking specific medications. 

Examples of such medical conditions include Hyponatremia, seizures, Bipolar disorder, Glaucoma, Diabetes, or heart disease.

If someone cannot use Sertraline for PE, they can consider other medications.

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Conclusion

Multiple studies have established that Sertraline for Premature Ejaculation is an effective treatment. 

Sertraline is available in three dosages, 25 mg, 50 mg, and 100 mg, suitable for managing PE.

People must consult a doctor before starting Sertraline for Premature Ejaculation because of some associated risks. 

Sertraline might cause some side effects of Sertraline, like nausea, headache, and diarrhea. 

It is unsuitable for people who have medical conditions like Diabetes or heart disease.

Sertraline can also interact with medications taken for other health conditions.

To explore this treatment option, one should consult a healthcare provider, follow their guidance, and be patient in achieving the desired results.

Frequently Asked Questions

Can Sertraline be used for sexual dysfunctions?

Sertraline is primarily used to treat Depression, Anxiety, and other mental health conditions. However, it has proven to help delay ejaculation. It may be used off-label for Premature Ejaculation with a doctor’s recommendation.

Are there any specific dosage guidelines for Sertraline in treating PE?

Yes, there are specific dosage guidelines for Sertraline in treating PE. The recommended starting dose of Sertraline is 25 mg daily. The dosage of Sertraline for Premature Ejaculation is usually lower than that used for treating Depression and is determined by a doctor.

How quickly does Sertraline improve Premature Ejaculation?

The time Sertraline takes to improve Premature Ejaculation depends on the individual’s response to the medication and the severity of their condition. Sertraline may take some time to show its effect on PE. It may take a month before an individual can notice the benefits of Sertraline for PE.

Can I use Sertraline for Premature Ejaculation on an as-needed basis?

Yes, you can use Sertraline for Premature Ejaculation on an as-needed basis. Some studies have shown that Sertraline can be effective when used as needed. However, it is important to talk to your doctor about the appropriate dosing and timing of Sertraline for your individual needs.

Citations:
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