Fluoxetine For Premature Ejaculation: Understanding How It Helps

Monali Sharma
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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fluoxetine for premature ejaculation

Premature Ejaculation is prevalent in almost 20 to 30% of males worldwide, making it one of the most common male sexual dysfunctions.

An individual with PE has an orgasm and releases semen sooner than desired in a sexual situation.

Healthcare professionals often prescribe Fluoxetine for Premature Ejaculation to manage the condition.

Interestingly, Fluoxetine is an antidepressant popularly known as Prozac.

But why is Fluoxetine used for Premature Ejaculation?

This article helps to understand the working of this antidepressant in treating PE and talks about its effectiveness, dosage, side effects, etc.

Early ejaculation may not be medically diagnosed as Premature Ejaculation if it happens after sex after a long time.

Does Fluoxetine help with Premature Ejaculation

Studies have concluded that Fluoxetine can treat Premature Ejaculation by significantly increasing the ejaculation time.

Fluoxetine is a medication to treat Depression and other disorders, and sometimes used off-label to treat PE too.

It is an SSRI, which means Fluoxetine increases Serotonin levels in the brain.

Serotonin carries signals between brain nerve cells and influences mood, emotion, and sleep.

One of the side effects of the medication is delayed ejaculation.

Serotonin has an inhibiting effect on orgasm and ejaculation, and Fluoxetine increases the levels of Serotonin in the brain.

The medication’s effect on Serotonin offers more control during sex and helps to manage Premature Ejaculation.

Therefore, Fluoxetine for Premature Ejaculation is a safe treatment that may help to prolong an orgasm by several minutes. 

Using Fluoxetine for Premature Ejaculation

If a doctor prescribes Fluoxetine for Premature Ejaculation, it should be used exactly as recommended.

Therefore, it is important to know the right Fluoxetine for PE dosage and when to take it for Premature Ejaculation.

Though there is no official dosage for Fluoxetine in PE, typically, a healthcare provider might advise taking 20 mg per day, subject to adjustment. 

The medication should be taken daily for effective Premature Ejaculation treatment.

Studies reported that people with PE experienced a greater delay in ejaculation after consuming Fluoxetine daily.

Risks of Fluoxetine for Premature Ejaculation

Nausea – side effectSource: AndreyPopov_from_Getty_Images
Nausea – side effect

Though Fluoxetine is a safe treatment option for PE, it may not be recommended for people with certain health conditions. 

A doctor does not recommend off-label use of Fluoxetine for individuals with a history of mental health, heart problems, low blood pressure, liver, or kidney complications.

The medication can cause various side effects, like anxiety, rapid heart rate, abnormal dreams, anorexia, insomnia, skin rashes, etc.

Severe side effects of Fluoxetine may include blurred vision, fainting, and seizures.

However, mild ones, such as dizziness, nausea, and headache, are commonly seen when taking this medication.

No one should take Fluoxetine without consulting a doctor.

It can cause other serious and potentially fatal side effects like Serotonin Syndrome, extremely low blood salt or Sodium levels, and Hypomania.

Furthermore, it can interact with other medications adversely, so the medication must be taken only under a doctor’s advice.

Do not take Fluoxetine without consulting a psychiatrist if you have a history of Depression or any mental disorder.
It has a black box warning for suicidal ideation.

Other options for treating PE

Various antibiotics in packetsSource: Denisfilm_From_Getty_Images
Various antibiotics in packets

Fluoxetine can successfully treat Premature Ejaculation.

However, it may only suit some due to potential side effects.

In other cases, people with PE need to consider alternative treatment options instead of Fluoxetine.

Besides Fluoxetine, over-the-counter topical treatments like delay sprays and other SSRI medications can also treat Premature Ejaculation.

These antidepressants are Paroxetine, Sertraline, Citalopram, and Dapoxetine.

Non-medical options are kegel or pelvic floor exercises and psychotherapy.

One can also try behavioral therapy, including physical techniques like the squeeze and start-stop techniques.

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Antidepressants like Fluoxetine can be used off-label to treat Premature Ejaculation effectively.

Multiple studies have established that Fluoxetine is a safe and successful treatment option for PE.

As an SSRI medication, it increases Serotonin, which causes delayed ejaculation as a side effect.

However, Fluoxetine has multiple potential side effects, from mild to severe and common to rare, and can cause rapid heartbeat, insomnia, anxiety, rash, seizures, etc.

It is not recommended for individuals with certain health issues, such as heart or kidney issues, as their medications might interact negatively with Fluoxetine and cause fatal reactions.

One may also be prescribed other SSRI medications, such as Paroxetine and Citalopram, for treating PE.

Non-medical and cost-effective techniques like kegel exercises and the squeeze technique may improve Premature Ejaculation symptoms, too.

But when deciding to use Fluoxetine for Premature Ejaculation, the first and most important thing to do is to consult a doctor to be able to take the medication safely.

Frequently Asked Questions

Does Fluoxetine treat Premature Ejaculation?

Yes, it has been studied various times that Fluoxetine can treat Premature Ejaculation effectively. It is an SSRI medication primarily used to treat health conditions like Depression. It works by increasing the Serotonin levels, which may help to delay ejaculation.

How to take Fluoxetine for Premature Ejaculation?

There is no fixed dosage of Fluoxetine for Premature Ejaculation. However, your doctor may suggest taking 20 mg of the medication in the beginning and adjust the dosage if needed. You may also be instructed to take Fluoxetine daily for an effective treatment.

What are other treatment options for Premature Ejaculation?

Fluoxetine is not the only medication or treatment option for Premature Ejaculation. Other treatment options for Premature Ejaculation include over-the-counter products, behavioral therapy like the start-stop technique, and other antidepressant medications such as Sertraline and Dapoxetine.

Are there any side effects of using Fluoxetine for Premature Ejaculation?

Fluoxetine for Premature Ejaculation may cause mild side effects like dizziness, nausea, and headache and severe side effects like blurred vision, fainting, and seizures. It may also cause anxiety, rapid heart rate, abnormal dreams, anorexia, insomnia, and skin rashes. Fluoxetine may also interact with other medications adversely.

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