Naproxen vs Naproxen Sodium: The Similarities and Differences 

Have you ever seen Naproxen and Naproxen Sodium written on the back of your medications and been confused as to whether they are different or the same? Both are painkillers, so they work very similarly. They are two commonly used Nonsteroidal Anti-inflammatory Drugs (NSAIDs) that help reduce hormones that cause inflammation, pain, and fever. 

While they share common goals, these medications have key differences. But what sets them apart, and when should you choose one? This article’s detailed comparison of Naproxen vs Naproxen Sodium reveals their nuances. Let’s compare and contrast the main features so you can pick the one that’s best for you.

Key features: Naproxen vs Naproxen Sodium

Are Naproxen and Naproxen Sodium the same?

Before the Naproxen vs Naproxen Sodium differences, let’s first look at the major similarities between the two.

Efficacy

Studies show that Naproxen is comparable to Naproxen Sodium in terms of efficacy. For instance, one study found both 400 mg Naproxen and 440 mg Naproxen Sodium significantly reduced pain compared to a placebo over 6 hours. Additionally, a review found Naproxen sodium as well as Naproxen superior in pain and symptom relief for primary Dysmenorrhea compared to Acetaminophen, Ibuprofen, and placebo.

Mechanism of action

They both work by inhibiting the Cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, responsible for producing Prostaglandins. Prostaglandins play an important function in producing pain and inflammation. By blocking the COX enzymes, Naproxen and Naproxen Sodium reduce Prostaglandin synthesis, decreasing pain and inflammation. 

Uses

Both the base and the salt form of Naproxen have similar uses. They effectively relieve pain, reduce inflammation, and control fever. They are also used as the first line of treatment for conditions like Arthritis and Bursitis.

Read What Is Naprosyn Used For to learn in detail about its uses and benefits.

Side effects

Both the forms have very similar side effect profiles, as they contain Naproxen as the active ingredient.

The most common side effects (generally mild) of both forms include

• Stomach pain
• Heartburn
• Nausea
• Dizziness
• Headache

However, the added Sodium in the salt form may increase the risk of water retention, swelling, and High Blood Pressure in some patients. Know more about the adverse effects by going through Naprosyn 500 Side Effects.

Contraindications

Both should be used cautiously or avoided if you have certain conditions. Some of these include:

• Severe heart disease
• History of stomach ulcers
• Kidney or liver issues
• Blood clotting disorders

Differences between Naproxen and Naproxen Sodium

Now, let’s uncover the significant Naproxen vs Naproxen Sodium distinctions.

Composition

Naproxen and Naproxen Sodium differ in chemical composition due to the Sodium content in the latter. 

The addition of Sodium alters its properties, making it a salt form of Naproxen. This difference in composition affects factors like solubility and absorption rates, with Naproxen Sodium being more soluble in water and having a faster absorption rate than Naproxen.

Dosage strength

Due to their formulations, they differ slightly in their dosage strengths. Even though Naproxen is slightly more concentrated per milligram, the recommended doses take this into account. 

For instance, 220 mg, 275 mg, or 550 mg of Naproxen Sodium is equivalent to 200 mg, 250 mg, and 500 mg of Naproxen, respectively. This means you can follow your doctor’s instructions for Naproxen dosages without having to worry about converting between the two forms.

Apart from those mentioned above, both the variations are available in different strengths allowing your healthcare professional to choose the right dosage for your specific condition.

Formulation

The main difference between the two is their formulations. Naproxen is available in various forms, including tablets, capsules, and suspensions, providing flexibility in administration. On the other hand, Naproxen Sodium is typically found in tablets and liquid gels, offering a more limited range of formulations. 

Naproxen Sodium is absorbed more quickly, with peak levels reached in 1-2 hours compared to 2-4 hours for Naproxen. This often becomes a determining factor when choosing between the two.

Choosing the right medication

Here’s how to pick between the two medications for your next bout with pain

• For fast relief: Naproxen Sodium might be your hero if you need immediate pain relief. Its quicker absorption gets you feeling better sooner
• For long-term relief: Consider extended-release Naproxen Sodium or regular Naproxen for long-lasting pain management
• In cases of stomach sensitivity: Regular Naproxen might be gentler on your stomach since it dissolves slower

Note:  Always consult your doctor before taking any medication, especially if you have underlying health conditions or take other medications. Follow the recommended dosages to avoid any unwanted side effects.

Conclusion

Understanding the similarities and differences between Naproxen and Naproxen Sodium is essential when deciding which to use. Both NSAIDs reduce pain, inflammation, and fever by blocking COX enzymes. 

Despite their similar efficacy, they differ in chemical composition: Naproxen is a base form, whereas Naproxen Sodium is a salt form, resulting in solubility and absorption rate variances. Naproxen is a somewhat stronger milligram for a milligram, but it absorbs more slowly, making it appropriate for long-term pain management. 

In contrast, Naproxen Sodium (Naprosyn 500) has a higher absorption rate, offering immediate relief for acute pain. Both types have identical side effects and contraindications. Always contact a healthcare expert to determine which drug is best for you.

Frequently Asked Questions

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