What Is Naprosyn Used For: 7 Major Indications

Monali Sharma
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Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
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The many uses of naprosyn

Naprosyn is a Non-Steroidal Anti-Inflammatory Drug (NSAID). It is a versatile medication known for its efficacy in treating pain or inflammation caused by various conditions. Its anti-inflammatory properties make it a preferred option for eliminating discomfort. 

Naprosyn is also known to have a favorable safety profile. It is available by prescription and over-the-counter (OTC) and in various forms, including tablets, capsules, and suspensions. However, as with any medication, it is essential to take it judiciously for the right reasons. So, you might ask, what is Naprosyn used for then?

Let’s delve into the primary Naprosyn indications and why it’s a go-to choice for many.

Naprosyn indications and uses

Naprosyn is used to treat a wide range of conditions. These include:

Rheumatoid Arthritis

Naprosyn (Naproxen) is commonly used to relieve the symptoms of Rheumatoid Arthritis, such as inflammation, swelling, stiffness, and joint pain. Studies have shown that Naprosyn is a useful medication for long-term use in people with Rheumatoid Arthritis, including those who were intolerant to or didn’t get adequate relief from other NSAIDs.

According to the FDA, clinical studies have found Naprosyn to be as effective as Aspirin in reducing disease activity in people with Rheumatoid Arthritis, with some people even reporting Naprosyn to be more effective. While Naprosyn did have some side effects like gastrointestinal issues, the incidence was lower than expected and not statistically significant compared to Aspirin. Overall, the studies conclude that Naprosyn is a valuable addition to the treatment options for Rheumatoid Arthritis.


Naprosyn effectively reduces Osteoarthritis (OS) symptoms such as pain, inflammation, and associated stiffness, making it a valuable treatment option for people with this condition. It decreases OA symptoms by inhibiting the development of specific natural chemicals that promote inflammation. 

For example, a study comparing how well non-prescription doses of Naproxen sodium and Ibuprofen relieve pain and how safe they are found that both medications effectively reduce pain and improve symptoms in people with mild to moderate knee OA.

Delayed-release or extended-release tablets are slower-acting versions of Naprosyn to treat chronic illnesses such as Arthritis or Ankylosing spondylitis. They do not work quickly enough to cure acute pain.

Ankylosing Spondylitis

Naprosyn is a valuable first-line treatment for Ankylosing Spondylitis (AS) patients, and it effectively reduces pain and inflammation associated with the condition. It prevents the formation of specific naturally occurring substances that aggravate inflammation, thereby reducing the symptoms of AS. 

Studies have shown that Naprosyn is effective at helping people with AS deal with pain and improve their ability to work. A study comparing the efficacy and tolerability of Aceclofenac and Naproxen in treating AS found that both medications effectively reduced symptoms.


A woman smiling after pain relief
A woman smiling after pain relief

Naprosyn is FDA-approved for treating Bursitis and is commonly used to relieve symptoms like inflammation, swelling, and mild to moderately severe pain. It does so by suppressing the creation of Prostaglandins, substances that aggravate pain and inflammation.


Gout is often associated with the inflammation of the joints, particularly the big toe. Naprosyn has been studied to provide relief for these symptoms. 

Studies have also shown that Naprosyn is an effective first-line treatment option for Gout in primary care settings. One study found no significant difference between Naprosyn and low-dose Colchicine in terms of improvements in pain intensity among Gout patients, but Naprosyn was better tolerated. 

Do not overuse Naprosyn. It can lead to stroke or heart attack.

Menstrual cramps

Naprosyn is also commonly used to relieve the pain and symptoms associated with menstrual cramps.

A study found that Naproxen sodium was “most effective in alleviating severe menstrual cramps” and was also helpful in easing some but not all of the subjective symptoms, including nausea, vomiting, and dizziness associated with menstrual pain. 

Post-surgery pain control

Naprosyn is effective in treating pain following various surgical interventions. It can help eliminate or reduce the need for rescue opioid medications in many cases.

More importantly, Naprosyn does not increase the risk of bleeding or other side effects when used in high-risk post-operative patients. This makes it a safe and useful choice in these situations.

Other uses of Naprosyn

In addition to the above conditions, there are a few other Naprosyn uses. It can relieve muscle aches, headaches, and dental pain and reduce fever if prescribed by a doctor.

If muscle aches persist or worsen even after using Naprosyn, it is advisable to consult a healthcare professional for further evaluation and management. Naprosyn has been shown to be effective in providing relief for acute migraine headaches, too.

Additionally, Naprosyn, when compared to other medications like Ibuprofen, is effective in providing relief for postoperative dental pain following procedures like tooth extractions. 

Furthermore, it is also used to reduce fever, particularly in the context of treating the conditions listed above. 


Naprosyn, or Naproxen, is a versatile Nonsteroidal Anti-Inflammatory Drug (NSAID) with a broad spectrum of applications, making it a cornerstone in managing pain and inflammation across various conditions. 

It has proven particularly effective in treating symptoms of Rheumatoid Arthritis, including inflammation, swelling, and joint pain, showcasing comparable efficacy to Aspirin but with lower gastrointestinal side effects. For Osteoarthritis and Ankylosing spondylitis, Naprosyn offers significant pain relief and improvement in joint function. 

It’s also FDA-approved for Bursitis and is a well-tolerated first-line treatment for Gout attacks. Naprosyn also addresses menstrual cramps by easing pain and associated symptoms, and it’s invaluable for post-surgery pain control, reducing reliance on opioids. 

Overall, Naprosyn’s broad applicability and favorable safety profile make it a preferred choice for managing pain-related conditions by doctors worldwide.

Frequently Asked Questions

How should Naprosyn be used?

Naprosyn should be taken orally as directed by a doctor, typically 2-3 times daily with a full glass of water. Taking it with food, milk, or an antacid is advisable to prevent stomach upset. The doctor should determine the dosage based on the medical issue and the course of treatment.

What is Naprosyn 500mg used for?

Naprosyn 500mg is primarily applied to reduce inflammation and pain related to several issues, such as Arthritis (Rheumatoid, Osteoarthritis, Ankylosing spondylitis), Gout, menstrual cramps, headaches, muscle aches, and Tendonitis. It works by blocking the production of substances that cause inflammation and pain.

How quickly does Naprosyn start working?

Naprosyn, a medication containing Naproxen, typically starts working within 1 to 4 hours after ingestion, with pain-relieving effects lasting for approximately 12 hours. For maximum efficacy and safety, adhere to the dosage and directions given by a medical practitioner.

What are the common side effects of Naprosyn?

Naprosyn, a pain-relieving medication, commonly causes side effects such as heartburn, nausea, vomiting, constipation, gas, stomach discomfort, blurry vision, headache, dizziness, drowsiness, bruising, itching, rash, swelling, and ringing in the ears. These side effects may vary in severity and duration, with some improving as the body adjusts to the medication.

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