Finding Relief: Naproxen for Toothache

Dinesh Patel
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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Relief at hand naproxen tackles toothache

Dealing with a toothache can be a relentless and excruciating experience. Whether it’s due to dental decay, infection, or other dental issues, finding effective relief is important. Finding relief becomes a top priority, whether the pain is a dull throb or a sharp, shooting pain. 

While there are various over-the-counter pain relievers available, one medication that can be effective is the NSAID Naproxen. 

This article will explore Naproxen’s effectiveness, dosage, and onset of action for toothache and compare it with other common pain relievers. 

Is Naproxen good for toothache

Naproxen’s primary function is alleviating pain, reducing inflammation, and lowering fever. When it comes to toothaches,  over-the-counter Naproxen can be effective in managing the discomfort associated with dental pain. Its anti-inflammatory properties help reduce swelling, relieving the associated pain.

Benefits of Naproxen for toothache

Naproxen’s effectiveness in relieving toothache pain and addressing inflammation makes it a valuable choice for dental discomfort.

  • Pain relief: Naproxen is known for its potent pain-relieving properties, making it effective in alleviating toothache pain
  • Anti-inflammatory action: By targeting inflammation, Naproxen addresses one of the underlying causes of toothache, providing both symptomatic relief and aiding in the healing process
  • Longer lasting: Compared to other over-the-counter pain relievers, Naproxen tends to have a longer duration of action, meaning it may provide relief for an extended period, reducing the need for taking it frequently

You can buy Naprosyn 500 + Naprosyn from WowRxPharmacy at an affordable price. 

Naproxen dosage for toothache

A spilled bottle of naproxen
A spilled bottle of naproxen

Naproxen, whether in its extended-release or immediate-release form, has effectively treated moderate to severe dental pain. A single dose of extended-release Naproxen sodium at 660 mg demonstrated significant pain reduction in a study. Moreover, it proved to be as effective as immediate-release Naproxen sodium taken at 220 mg three times a day.

This dosage regimen provided rapid relief, with noticeable pain reduction starting as early as 15 minutes after administration and lasting 24 hours. As a result, there was a decreased requirement for additional pain medication.

Naproxen and Amoxicillin for toothache

Naproxen and Amoxicillin are commonly prescribed medications for treating toothache, especially when caused by a bacterial infection. Amoxicillin can target the bacteria that have infiltrated the tooth’s pulp, helping to eliminate the infection. 

When managing tooth infections, a combination of Amoxicillin and Naproxen may be prescribed to address the bacterial infection and the pain and inflammation. While Amoxicillin targets the root cause of the infection by eliminating bacteria, Naproxen provides symptomatic relief by reducing pain and swelling. 

It’s important to take these medications as directed by healthcare professional. 

Amoxicillin can also treat infections such as strep throat or ear infections, and it has fewer gastrointestinal side effects than other antibiotics. 

Naproxen vs Ibuprofen for toothache

Naproxen and Ibuprofen are Nonsteroidal Anti-inflammatory Drugs (NSAIDs), used to relieve pain and inflammation, including toothaches. Both can be effective, but their suitability may depend on factors such as your medical history and other medications you’re taking.

To know which medication is more suitable for dental pain, this comparison can be helpful in determining the best option for you. 

Speed of ActionTakes up to an hour to workWorks in 20 to 30 minutes
Duration of ReliefLasts longer, usually every 6-8 hours or longer, depending on the formulationLasts shorter, usually every 4-6 hours
StrengthTypical adult dose: 220 mg, can take up to 660 mg initiallyTypical adult dose: 200 mg every 4-6 hours; max 1,200 mg in 24 hours
Suitability for ChildrenGenerally not recommended for children, especially who are younger than 12 yearsGenerally suitable for children, the dosage varies with age
Side EffectsNaproxen carries a higher risk of gastrointestinal side effects compared to Ibuprofen due to its long-acting nature. Higher risk due to prolonged activityIbuprofen generally has a lower risk of GI side effects compared to Naproxen due to its shorter duration of action.
Cardiovascular ConsiderationsNaproxen is often preferred over Ibuprofen in individuals with pre-existing heart conditions due to its favorable cardiovascular profile. Ibuprofen may pose a higher risk of cardiovascular events compared to Naproxen, particularly at higher doses or in individuals with underlying heart conditions.

Side effects and interactions

When taking Naproxen for a toothache, it’s important to be aware of potential side effects and interactions.

Side effects

Naproxen can effectively manage pain and inflammation. However, like any medication, it comes with potential side effects. 

  • Gastrointestinal issues: Naproxen can cause stomach irritation, causing symptoms such as stomach pain, nausea, vomiting, indigestion, or heartburn.
  • Increased risk of ulcers: Long-term use or high doses of Naproxen increases the risk of developing ulcers in the stomach or intestines
  • Bleeding: Naproxen may interfere with blood clotting, increasing the risk of bleeding, especially if you have certain medical conditions like hemophilia or those taking blood thinners
  • Kidney problems: Prolonged use of Naproxen can lead to kidney damage or worsen pre-existing kidney conditions
  • Allergic reactions: Some individuals may get allergic reactions to Naproxen
Seek immediate medical help if you experience symptoms like skin rash, swollen glands, muscle aches, unusual bruising, or yellowing of skin/eyes, as it indicates you are allergic to Naproxen. 


Understanding potential drug interactions is important for effective management. When considering Naproxen for toothache, you should know how it interacts with other medications.

  • Other NSAIDs: Use of Naproxen with other nonsteroidal anti-inflammatory drugs like Ibuprofen or Aspirin may increase the risk of gastrointestinal bleeding
  • Blood thinners: Taking Naproxen with anticoagulant medications like Warfarin can increase the risk of bleeding
  • Corticosteroids: Use of Naproxen with Corticosteroids may increase the risk of gastrointestinal ulcers and bleeding
  • ACE inhibitors and diuretics: Naproxen can reduce the effectiveness of some blood pressure medications like ACE inhibitors, leading to increased blood pressure
  • Alcohol: Drinking excessive alcohol while taking Naproxen can increase the likelihood of gastrointestinal bleeding and liver damage


Naproxen is an effective option for managing toothache’s relentless discomfort, relieving pain, and reducing inflammation. One of the primary benefits of Naproxen for toothache is its potent pain-relieving action. Toothaches can range from dull throbs to sharp, shooting pains, and Naproxen is adept at providing relief across this spectrum. 

Moreover, Naproxen’s extended action duration distinguishes it from other over-the-counter pain relievers. A single dose of extended-release Naproxen sodium at 660 mg demonstrated significant pain reduction, comparable to immediate-release Naproxen sodium taken at 220 mg three times a day. 

In cases where toothache is accompanied by bacterial infection, a combination of Naproxen and antibiotics like Amoxicillin may be prescribed. While Amoxicillin targets the root cause of the infection by eliminating bacteria, Naproxen provides symptomatic relief by reducing pain and swelling.

Naproxen can cause side effects like Gastrointestinal issues, such as stomach irritation and ulcers. 

Naproxen effectively relieves toothache, addressing both pain and inflammation associated with dental pain. It is important to follow the dosage instructions and monitor it for potential side effects and interactions. 

Frequently Asked Questions

Does Naproxen work for toothache?

Yes, Naproxen can be effective for managing toothache. As a Nonsteroidal Anti-Inflammatory Drug (NSAID), Naproxen helps alleviate pain and reduce inflammation, a common symptom of toothaches. Its anti-inflammatory properties can target the underlying causes of toothache, relieving discomfort.

Which is better for tooth pain, Naproxen or Ibuprofen?

Both medications are commonly used to relieve toothache pain. The choice between the two may depend on your medical history, existing medical conditions, and the severity of your tooth pain. While both medications can be effective, some may find one more suitable or tolerable. 

Is Naproxen 500 mg a strong painkiller for toothache?

Naproxen 500+ mg is considered a higher dose and can be effective for managing moderate to severe toothache. However, the appropriate dosage of Naproxen for toothache depends on individual factors. WowRxPharmacy has Naprosyn 500 + available at affordable prices, which can be suitable for relief from severe dental pain.

How much Naproxen can I take for a toothache?

The recommended dosage of Naproxen for toothache typically depends on factors such as your age, weight, medical history, and the severity of your toothache. Generally, the initial dose of Naproxen for adults is 220 mg, which can be repeated every 8 to 12 hours as needed.

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