Can You Take Tylenol With Naproxen For Double Benefit?

Monali Sharma
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

Published On:

When you’re in pain, popping medications like candy sounds good, but it can be risky. Imagine battling a relentless migraine or severe Arthritis pain and wondering if combining Tylenol (Acetaminophen) with Naproxen might provide double the relief. 

So, can you take Tylenol with Naproxen at the same time for a super dose of comfort?  Surprisingly, the answer isn’t as straightforward as you might think. While they might seem like close cousins on the medicine cabinet shelf, these two medications work very differently.

Even though some healthcare providers may recommend combining these drugs, taking Tylenol and Naproxen together could increase your chances of developing stomach ulcers or kidney problems.

Curious to learn more? Read on to learn the facts about this medicine combo and decide for yourself if the benefits outweigh the risks.

Can you take Naproxen with Tylenol?

Yes, in most cases, it is safe to take Tylenol with Naproxen. Tylenol is commonly used for mild to moderate pain relief and to reduce fever, while Naproxen (Naprosyn 500) is often used to ease the pain of many conditions, including Arthritis, headaches, toothaches, menstrual cramps, and more.

Both Naprosyn and Tylenol belong to different classes of pain relievers, work differently to alleviate pain, and have different mechanisms of action, making them safe to use together for many people.

However, you must follow the dosage instructions carefully and not exceed the recommended amounts. Exceeding the dose can lead to adverse effects and diminish the potential benefits of these drugs. Combining Naproxen and Tylenol may allow you to take a lower dose of Naproxen while still achieving the same pain relief. They can also be taken together alternately to provide better pain relief. It’s also crucial to consult a doctor before taking these medicines together, especially if you already have a health problem or are taking other medicines. 

You can learn about Naproxen dosage by reading Naprosyn Dosage Per Day: What Should It Be.

Tylenol can be taken every 4-6 hours, while Naproxen is usually dosed every 8-12 hours.

How does Tylenol and Naproxen work

Tylenol and Naproxen work differently to provide pain relief. Tylenol blocks the release of substances in the brain that cause pain sensation. It is an analgesic and antipyretic, inhibiting pain sensors in the nervous system and reducing fevers. Acetaminophen does not reduce inflammation but focuses on reducing pain perception in the brain. 

Naproxen blocks the formation of substances that cause inflammation. By reducing inflammation, Naproxen helps to alleviate pain. It belongs to the class of NSAIDs, which work by decreasing the chemicals that trigger inflammation in the body. You can easily buy Naprosyn 500 tablets from WowRxPharmacy at affordable prices.

Pros and cons of taking Tylenol with Naproxen

The following table summarizes the potential benefits and hazards of combining Tylenol and Naproxen:

Benefits of CombiningRisks of Combining
Enhanced efficiency at relieving painIncreased risk of liver damage
Added pain-relieving benefits for various types of pain Stomach issues like ulcers or bleeding
Allows for taking lower Naproxen dosesCardiovascular problems with prolonged use
Increase in Naproxen’s potencyAllergic reactions
Helps manage chronic painInteractions with other medications
Relief for a longer periodKidney damage (for high doses/prolonged use)
Rapid fever reductionOverdose and serious health issues
Additional anti-inflammatory effects

Never mix these medications without first speaking with a medical practitioner. Based on your health and medical background, they can offer tailored guidance about Naproxen interactions and other precautions you must take.

Things to consider before taking Tylenol and Naproxen together

It is essential to take certain things into consideration while taking multiple medications together. These include:

Side effects

When taken together, Tylenol and Naproxen may increase the risk of certain side effects, such as:

  • Gastrointestinal problems: Issues such as stomach pain, ulcers, bleeding, heartburn, nausea, vomiting
  • Kidney problems: Both medications can affect kidney function, especially with prolonged use
  • Liver damage: Particularly from Tylenol, especially if taken in high doses or combined with alcohol
  • Allergic reactions: From minor skin rashes to serious reactions requiring medical treatment
  • It’s important to follow your healthcare provider’s dosage instructions and not exceed the recommended amounts of either medication.

Who shouldn’t take Tylenol and Naproxen together?

People with certain conditions should exercise caution or avoid taking these medications together, including

  • People with a history of stomach ulcers or gastrointestinal bleeding
  • Those with kidney or liver disease
  • Individuals who consume excessive amounts of alcohol
  • Pregnant or breastfeeding women
  • People on other medications, such as other NSAIDs, anticoagulants, or certain blood pressure medications

Combining Tylenol and Naproxen can be effective for managing pain and inflammation, but it is essential to do so safely and under the guidance of a healthcare professional.

Do not give more than 5 doses of Tylenol in 24 hours to children under 12 years old, as this can lead to an overdose and liver damage.


Generally, it’s safe to take Tylenol with Naproxen together for enhanced pain management and potentially faster fever reduction. Tylenol, known for its pain-relieving and fever-reducing abilities without anti-inflammatory effects, complements Naproxen’s strength in reducing inflammation and pain associated with various conditions. 

However, exceeding the recommended amount or mixing it with other medications can pose major health hazards. While this combination can enhance pain management and potentially allow for lower doses of each medication, it’s essential to adhere to recommended dosages and consult a healthcare professional to avoid risks such as liver damage, stomach issues, and potential drug interactions. 

Before mixing these medications, see your doctor, especially if you have any underlying health issues or are taking other medications. They can advise you on the best course of action based on your specific needs and medical history.

Frequently Asked Questions

Is Tylenol and Paracetamol the same?

Yes, Tylenol and Paracetamol are the same drug. Tylenol is the brand name used in the U.S., while Paracetamol is the generic name used internationally. They have the same chemical composition and medical uses.

How long after taking Naproxen can I take Paracetamol?

You can take Paracetamol at the same time as Naproxen, as they are safe to use together. There is no recommended time interval between taking the two medications, and you don’t have to adjust your doses of either drug, too. However, taking the medications alternately may help provide better pain relief.

Is Naproxen stronger than Tylenol?

Due to its anti-inflammatory properties, Naproxen is generally considered stronger than Tylenol for pain relief. However, the choice between them is based on your doctor’s prescription, the condition, and your response to the medication.

What should you not mix with Tylenol?

Avoid mixing Tylenol with alcohol, other medications containing Acetaminophen, and Warfarin to prevent liver damage and potential overdose risks. It’s crucial to consult healthcare providers before combining Tylenol with other substances or medications.

WowRxPharmacy uses only high-quality sources while writing our articles. Please read our content information policy to know more about how we keep our content reliable and trustworthy.

More Articles Like This

Leave a Comment

Receive the latest articles in your inbox!