A Comprehensive Guide to Levofloxacin Side Effects

Amisha Jain
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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levofloxacin side effects

Levofloxacin is a powerful antibiotic from the Fluoroquinolone family, commonly prescribed to combat a range of bacterial infections. 

However, like any medication, it is essential to be aware of potential side effects to make informed decisions about your health. 

Its side effects can range from manageable ones like headaches to rare but serious ones such as irregular heartbeat.

Moving ahead, we will discuss some common and rare Levofloxacin side effects, shedding light on what you need to know about this medication before taking it.

Common side effects of Levofloxacin

While Levofloxacin’s efficacy is well-documented, potential side effects could arise during its usage. 

Note that not every individual experiences these side effects, and some individuals may only encounter mild symptoms. 

Some of these common side effects include:

Gastrointestinal distress

Nausea, vomiting, diarrhea, and stomach pain are frequently reported Levofloxacin side effects. 

Staying hydrated and taking the medication with food can help alleviate these symptoms.

Headache and dizziness

Some individuals might experience headaches or dizziness. 

It is advisable to avoid activities requiring focus and balance if you encounter these symptoms.

Sensitivity to sunlight

Levofloxacin can increase your skin’s sensitivity to sunlight, potentially leading to sunburn more quickly than usual. 

Applying sunscreen and wearing protective clothing can mitigate this effect.

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Rare but serious Levofloxacin side effects

While most individuals tolerate Levofloxacin well, it’s essential to acknowledge the possibility of less common but more severe side effects. 

If you experience any of the following symptoms, it’s crucial to seek medical attention promptly:

Tendon rupture or tendinitis

Although rare, Levofloxacin has been associated with an increased risk of tendon rupture and tendinitis. 

If you notice tendon pain or swelling, discontinue the medication and consult your healthcare provider.

Tendinitis is the inflammation of the tendons, which are the thick fibrous chords attaching the muscle to the bone.

Peripheral neuropathy

Levofloxacin can cause damage to peripheral nerves, leading to symptoms like tingling, numbness, and weakness in the extremities. 

If you experience these sensations, inform your doctor.

Allergic reaction

swelling of the face or throat, and difficulty breathingSource: jevelin_from_Getty_Images
Allergic reaction to medication

An allergic reaction to Levofloxacin may manifest as hives, swelling of the face or throat, and difficulty breathing.

It might also induce a skin reaction, causing fever, sore throat, rash, and burning sensation on the skin or in the eyes.

Even though it is a rare complication, it is suggested to consult your doctor immediately if you notice any of the signs of these allergic reactions. 

Cardiac effects

In some cases, Levofloxacin may lead to irregular heart rhythms, especially in individuals with pre-existing cardiac conditions. 

If you notice palpitations or a rapid heartbeat, medical attention is crucial.

Considerations for specific populations

Certain populations might be more vulnerable to certain Levofloxacin side effects. 

Elderly individuals and children, for instance, are at a higher risk of tendon issues. 

Pregnant and breastfeeding women should exercise caution, as studies on the medication’s safety for unborn babies and infants are limited. 

Consulting a healthcare professional before taking Levofloxacin is particularly crucial for these populations.

Consult your healthcare provider before you begin or discontinue any medication. Seek prompt medical assistance in case you experience severe symptoms or adverse effects while taking Levofloxacin.

Precautions and interactions

Communicate openly with your healthcare providerSource: SHOTPRIME
Communicate with your doctor about the side effects

To ensure your safety while taking Levofloxacin, it is crucial to communicate openly with your healthcare provider. 

Inform them of any pre-existing medical conditions, medications, or supplements you are taking. 

Certain medications, such as NSAIDs (Non-steroidal Anti-inflammatory Drugs), can interact with Levofloxacin and increase the risk of side effects. 

Your doctor can determine if Levofloxacin is the right choice for you and adjust the dosage or recommend alternatives if necessary.


Levofloxacin is a potent weapon against bacterial infections. However, its use comes with responsibilities. 

Understanding the potential Levofloxacin side effects and being vigilant for any adverse reactions is essential for your well-being. 

Common side effects like gastrointestinal discomfort and headache are generally manageable.

The rare but serious effects, like tendon rupture, allergic reaction, and cardiac irregularities, require immediate attention. 

By staying informed, openly communicating with your healthcare provider, and adhering to their guidance, you can harness the benefits of Levofloxacin while minimizing its potential risks.

Frequently Asked Questions

What is the most serious side effect of Levofloxacin?

One of the most serious side effects of Levofloxacin is the risk of tendon rupture, particularly involving the Achilles tendon. This can cause significant pain, swelling, and impaired mobility, requiring immediate medical attention.

What are the risks of taking Levofloxacin?

Risks associated with Levofloxacin use include the potential for serious side effects like tendon rupture, peripheral neuropathy, and cardiac irregularities. There is also an increased risk of developing antibiotic resistance with improper or unnecessary use.

Who should avoid Levofloxacin?

Certain individuals should avoid Levofloxacin, including pregnant and breastfeeding women, due to limited safety data. Additionally, those with a history of tendon issues, known allergies to Fluoroquinolones, or a predisposition to seizures should seek alternative treatments.

What to avoid while taking Levofloxacin?

While taking Levofloxacin, it’s advisable to avoid direct sunlight exposure, as the medication can increase skin sensitivity, leading to sunburn. Additionally, you should avoid taking antacids, vitamins, or minerals within two hours of Levofloxacin to prevent potential interactions that reduce its effectiveness.

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