Antibiotic for Kidney Infection: A Guide to Treat Pyelonephritis

Dinesh Patel
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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Best antibiotics for kidney infections

Kidney infections, medically known as Pyelonephritis, are Urinary Tract Infections that begin in the bladder or urethra and travel to one or both kidneys. This type of UTI is serious and requires prompt medical attention to prevent complications like kidney damage or sepsis.

About one in 30 cases of UTI results in a kidney infection. Antibiotics are the primary form of treatment for kidney infections, and understanding their use is essential for effective management and recovery.

This article will explore various antibiotic for kidney infection and which antibiotic is the best for kidney infection. 

What causes bacterial kidney infection?

Bacterial kidney infections typically begin as a lower Urinary Tract Infection (UTI), which can progress upward to affect the kidneys. The most common bacterial agent is Escherichia coli (E. coli), a bacterium that resides harmlessly in the intestines but causes infection when it enters the urinary tract. 

Here’s a closer look at how these infections develop:

E. coli transmission

E. coli bacteria can be transferred from the anus to the urethra during activities such as sexual intercourse or improper wiping after a bowel movement. Once in the urethra, the bacteria can move up to the bladder, leading to Cystitis (bladder infection), and further travel to the kidneys.

Women are also at higher risk of contracting bladder infection due to the shorter length of the urethra. The shorter length makes it easier for bacterial access to the bladder.

Other bacterial causes

While E. coli is the most common culprit, other bacteria like Klebsiella, Proteus, and Enterococcus can cause kidney infections. These bacteria follow similar pathways to reach the kidneys.

Strong antibiotics for kidney infection

The selection of antibiotics for kidney infections depends on several factors. These include the severity of the infection, the individual’s medical history, and the bacteria causing the infection. Here are some strongly prescribed antibiotics:


It is a penicillin-based antibiotic combined with a beta-lactamase inhibitor. Augmentin is useful for infections caused by bacteria that are resistant to other antibiotics. It is typically taken for 10 to 14 days.

You can easily find Augmentin 375 Augmentin at WowRxPharmacy at affordable prices.


It belongs to a group of Sulfonamide antibiotics and is effective against various bacteria. It is typically prescribed for mild to moderate kidney infections. The required dosage and treatment duration vary based on the severity of the infection. 

Fluoroquinolone (Ciprofloxacin/ Levofloxacin)

These medications are effective for more severe infections and are often used when the patient has a complicated UTI or kidney infection. These antibiotics are usually taken for 7 to 14 days.

Ceftriaxone (Rocephin)

In severe cases, Ceftriaxone is often used. It is administered intravenously, making it suitable for hospital settings. The IV is followed by oral antibiotics to complete the treatment course. The typical duration of treatment is around 10-14 days. 

It is important to take the medications as prescribed by the doctor. Improper use of antibiotics can cause resistance, making kidney infections difficult to treat.

Amoxicillin for kidney infection

Amoxicillin is a widely used antibiotic that is effective against various bacterial infections, including those affecting the kidneys. A study found that a dose of 2500 mg of Amoxicillin could be appropriate for treating kidney infections caused by certain strains of bacteria. This dose is recommended for treating about 43% of the types of bacteria found.

Mechanism of action

Amoxicillin hinders the synthesis of bacterial cell walls. It targets the penicillin-binding proteins within the bacterial cell membrane and eradicates Escherichia coli (E. coli) and other gram-negative bacteria.

Dosage and duration

The dosage of Amoxicillin for a kidney infection depends on the severity of the infection and the patient’s overall health condition. The treatment typically lasts from 7 to 14 days, depending on the response to the medication and the severity of the infection.


Amoxicillin is highly effective in treating bacterial kidney infections, particularly when susceptible strains of bacteria cause the infection. Clinical improvement is usually observed within a few days of starting treatment, although it is crucial to complete the full course of antibiotics to prevent recurrence and resistance.


Kidney infections, or Pyelonephritis, require prompt and effective antibiotic treatment to prevent complications like kidney damage and sepsis. Bacterial agents, particularly Escherichia coli, are the primary causes of these infections, often coming from lower urinary tract infections. 

The type of antibiotic prescribed depends on the severity of the infection and the specific bacteria involved. Commonly prescribed antibiotics include Amoxicillin/Clavulanate, Trimethoprim, Ciprofloxacin, Levofloxacin, Ceftriaxone, and Aminoglycosides. They are each selected based on their efficacy against the bacteria that causes infection and specific factors.

Amoxicillin is a frequently used antibiotic for kidney infections. It is effective against E.coli bacteria and is generally well-tolerated. Proper adherence to the prescribed treatment is crucial for successfully eradicating the infection and preventing antibiotic resistance.

Timely medical intervention and appropriate antibiotic therapy are essential for managing kidney infections, ensuring recovery, and maintaining renal health.

Frequently Asked Questions

Does Amoxicillin treat kidney infection?

Yes, Amoxicillin can treat kidney infections, particularly those caused by Escherichia coli (E. coli). As a penicillin-class antibiotic, Amoxicillin stops the synthesis of bacterial cell walls, which can eradicate the infection.  Augmentin 375 Amoxicillin is easily available at WowRxPaharmacy, and you should take the full course of Amoxicillin as prescribed. 

What causes kidney infections in females?

Kidney infections in females are typically caused by bacteria entering the urinary tract and going to the kidneys. Several factors increase the risk of kidney infections, such as sexual activity, improper wiping after a bowel movement, urinary tract abnormalities, diabetes, or a weakened immune system. 

What is the strongest antibiotic for kidney infection?

The strongest antibiotic for a kidney infection depends on the bacteria type causing the infection and the patient’s medical history. Some of the most effective antibiotics used in these cases include Augmentin, Ceftriaxone (Rocephin), and Aminoglycosides. Ciprofloxacin and Levofloxacin are effective for more severe or complicated infections. 

Is 3 days of antibiotics enough for a kidney infection?

Typically, 3 days of antibiotics is not enough to treat a kidney infection. These infections generally require longer antibiotics to eradicate the bacteria completely. The standard treatment duration for kidney infections usually is 7 to 14 days and it depends on the severity of the infection. 

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