What Causes Estrogen Dominance: Understanding the Reasons

Amoha Jha
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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what causes estrogen dominance

Estrogen dominance is a term that has gained attention in recent years due to its potential impact on health and well-being. 

Understanding the many factors contributing to this hormonal imbalance is crucial.

It helps individuals seeking to manage their health and healthcare professionals aiming to provide targeted interventions. 

From medications to genetics, there can be various reasons for Estrogen dominance.

This article gives a detailed answer to what causes Estrogen dominance.

Causes of Estrogen dominance

Estrogen dominance can stem from various underlying mechanisms. 

Here are the prime reasons:

  • Overproduction of Estrogen within the body
  • Changes in Estrogen metabolism and excretion 
  • Imbalance in the Estrogen-to-Progesterone ratio

These things can happen due to various factors. Let’s discuss them in detail.

Factors influencing Estrogen dominance

Here are the underlying factors that can cause changes in Estrogen levels and result in its higher amounts in the body:


Medicines, often prescribed with the best of intentions, can sometimes disrupt hormonal balance. 

Certain drugs, such as Estrogen therapy, can influence Estrogen levels.

Estrogen therapy involves the administration of synthetic or naturally derived Estrogen hormones to address hormonal imbalances, manage menopausal symptoms, or treat certain medical conditions related to Estrogen deficiency.

Body fat

Body fat due to low EstrogenSource: Africa_images
Body Fat

Body fat plays a role in hormonal regulation. 

Adipose tissue (commonly known as body fat) is a site for Estrogen metabolism, and excess body fat can increase Estrogen levels. 

This phenomenon is particularly relevant in postmenopausal women, as fat cells become a primary source of Estrogen after ovarian Estrogen production declines.


Modern life’s fast pace can lead to chronic stress, which disrupts the body’s hormone balance. 

Stress triggers the release of Cortisol, often called the stress hormone. 

Increased stress can cause lower levels of Progesterone, hindering the Estrogen-to-Progesterone ratio, potentially resulting in Estrogen dominance.

Stress can be a triggering factor for various health issues. Consult your healthcare professional if you experience chronic or extreme stress levels.

Alcohol consumption

Alcohol can result in an Estrogen buildupSource: ElenaNichizhenova_from_Getty_Images
Avoid alcohol

Excessive alcohol consumption can impair liver function, resulting in hormonal disturbances.

Alcohol may hinder the liver’s ability to metabolize Estrogen and other hormones effectively. 

This can result in an Estrogen buildup, worsening the dominance issue.

Liver problems

A healthy liver plays a vital role in metabolizing and excreting excess hormones from the body. 

Liver dysfunction can lead to inefficient Estrogen clearance, contributing to Estrogen dominance.

Conditions like fatty liver disease or liver inflammation can impair this vital function.

Synthetic Xenoestrogens

Synthetic Xenoestrogens are compounds found in plastics, pesticides, and certain industrial products that mimic the effects of Estrogen in the body. 

These endocrine-disrupting chemicals can interfere with hormone balance and contribute to Estrogen dominance.


The gut microbiome has far-reaching effects on health, including hormonal balance. 

Dysbiosis, an imbalance in gut bacteria, can affect Estrogen metabolism and lead to increased levels of Estrogen in the body.

Health conditions

Certain health conditions, such as Polycystic Ovary Syndrome (PCOS), can disrupt hormone production.

Women with PCOS may produce excess Estrogen, contributing to Estrogen dominance. 


Some tumors, particularly those in the ovaries or adrenal glands, can produce excess Estrogen. 

These hormone-secreting growths can lead to Estrogen dominance, necessitating medical intervention.


Genetic predisposition can influence how an individual’s body processes and metabolizes hormones. 

Some people may be more prone to Estrogen dominance due to genetic makeup.


Understanding the causes of Estrogen dominance is crucial for both individuals and healthcare professionals. 

Various factors contribute to this hormonal imbalance, including the overproduction of Estrogen, changes in metabolism, and an imbalance in the Estrogen-to-Progesterone ratio. 

Factors like medications, body fat, stress, liver problems, health conditions, tumors, and genetics influence Estrogen dominance. 

Recognizing these influences empowers individuals to make informed choices about their health.

Healthcare providers can also provide the right advice to address the underlying causes. 

A comprehensive approach is essential for managing and preventing Estrogen dominance for overall well-being.

Recommended Reading
Read Effective Approaches for Estrogen Dominance Treatment to learn how to treat Estrogen dominance.

Frequently Asked Questions

What is the most common cause of Estrogen dominance?

Excessive body fat is a prevalent cause of Estrogen dominance. Adipose tissue serves as a site for Estrogen metabolism, leading to increased Estrogen levels. Particularly in postmenopausal women, excess body fat becomes a primary source of Estrogen as ovarian production declines, contributing to hormonal imbalance.

Can birth control cause Estrogen dominance?

Yes, certain birth control methods can potentially contribute to Estrogen dominance. Hormonal birth control containing synthetic Estrogen may disrupt the natural hormone balance, leading to elevated Estrogen levels. However, the impact varies among individuals, and healthcare providers should be consulted to determine the best contraceptive choice for hormonal health.

What causes high levels of Estrogen?

High Estrogen levels can result from factors like excessive body fat, Estrogen therapy, impaired liver function, exposure to synthetic Xenoestrogens in plastics/pesticides, gut Dysbiosis altering Estrogen metabolism, certain health conditions, and hormone-secreting tumors in ovaries or adrenal glands.

Can obesity cause higher Estrogen levels?

Yes, obesity can lead to higher Estrogen levels. Adipose tissue (body fat) can produce Estrogen, contributing to hormonal imbalance. In postmenopausal women, as ovarian Estrogen production decreases, excess body fat becomes a significant source of Estrogen, disrupting the Estrogen-to-Progesterone ratio and potentially causing Estrogen dominance.

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