Estrogen Patch Side Effects: All You Need To Know

Amisha Jain
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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estrogen patch side effects

Estrogen patches are more commonly called Estradiol patches, which is a primary form of the hormone Estrogen.

The Estrogen patch significantly reduces a variety of issues, including symptoms connected to Menopause.

It may, however, potentially have negative effects, just like any medication.

Although most Estrogen patch side effects are mild and temporary, it is still important to be aware and vigilant.

By being aware of any potential adverse effects, one can seek immediate treatment choices and medical attention if necessary.

Read along to learn the side effects of Estrogen patches in detail to ensure proper management.

Side effects of Estrogen patches

Like every medication, transdermal patches also have side effects.

Some of the most commonly seen Estrogen patch side effects include:

  • Back pain
  • Breast pain and tenderness
  • Changes in vaginal discharge or fluids
  • Headache
  • Indigestion

Some other observable side effects include:

Skin inflammation

In some cases, a transdermal patch may affect the skin, causing:

  • Skin irritation
  • Intense redness
  • Blistering
  • Persistent itching

Some individuals might also experience redness, swelling, burning, irritation, or itching of the vagina irrespective of the placement of the patch.

Allergic reaction

Skin rashes and skin allergySource: AboutnuyLove_from_Getty_Images
Skin allergy (Itching)

A very serious allergic reaction is rare while using a transdermal patch.

However, some people may experience an allergic reaction to them, which may manifest as:

  • Skin rash
  • Itching
  • Hives
  • Difficulty in breathing
  • Face, lips, tongue, or throat swelling

 If you experience any of these symptoms, seek immediate medical attention.

Pain or swelling

One of the Estrogen patch side effects is pain or swelling in the legs, chest, jaw, or left arm.

Some people might also experience:

  • Swelling or redness in the legs
  • Weakness on one side of the body
  • Tinkling or numbness in arms and legs

Vaginal bleeding

The initial few months of applying an Estrogen patch may result in irregular vaginal bleeding or spotting.

Usually, with time, this bleeding or spotting lightens, becomes less frequent, and finally ceases as your body gets used to the medication.

It is crucial to let your doctor know if you encounter severe bleeding or if spotting or bleeding persists despite receiving medication for a few months.

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Changes in weight

Although Estrogen patches do not often cause weight gain, some people may suffer mild to moderate weight increases. 

This is because hormonal changes may affect appetite and metabolism, which might result in weight gain. 

You can manage these weight fluctuations by leading a healthy lifestyle with regular exercise and nutritious food. 

If you are worried about weight gain, ask your healthcare professional for advice.

Cardiovascular issues

It has been found that hormone replacement therapy, including the use of Estrogen patches, may be linked to a slightly higher chance of cardiovascular issues.

These include lead to an increased risk of

  • Blood clot
  • Stroke
  • Heart attack
  • Chest pain
  • Coughing blood

Mood changes

Some individuals on Estrogen patches may observe frequent mood changes, including depression, anxiety, and thoughts of self-harm or suicide.

Some people also suffer memory loss as a result of these transdermal patches.

Seek immediate medical attention if you experience dark urine, persistent nausea, or severe abdominal pain.

Other side effects of Estrogen patch

Some other side effects, though rare, but might be observed in some individuals who use transdermal patches include:

  • Yellowing of the skin
  • Loss of appetite
  • Difficulty breathing or swallowing
  • Change in sexual desire
  • Difficulty wearing contact lenses
  • Painful menstrual periods
  • Vision changes

Depending on the person and how their body reacts to the medication, Estrogen patch side effects last for varying lengths of time.

While some side effects may disappear without therapy, others can persist as your body gets used to the drug.

Side effects like minor skin irritation or headaches may go away in a few days or weeks. 

On the other hand, changes in weight may necessitate ongoing treatment and alterations to lifestyle. 

Remember that every individual reacts differently to every medication. 

To properly manage the side effects, it’s crucial to disclose your entire medical history with your doctor for appropriate treatment.

When to see a doctor

consult a doctor for effective treatmentSource: studioroman
Consult a Doctor

It is crucial to consult a doctor in case the side effects persist for a long time or cause discomfort.

Also, visit a doctor immediately in case of a suspected overdose, as your doctor might need to make adjustments to the dosage.

Estrogen patches come in various strengths of 0.025 mg/day, 0.05 mg/day, 0.075 mg/day, or 0.1 mg/day.

This might show up as:

  • Nausea and/or vomiting
  • Breast tenderness
  • Abdominal pain
  • Drowsiness and fatigue
  • Vaginal bleeding


Estrogen or Estradiol patches can have side effects that might differ from mild to severe.

They include severe skin conditions, vaginal bleeding, changes in weight, allergic reactions, pain or swelling, signs of blood clots, mood changes, and various other symptoms.

Some side effects may be temporary and resolve over time as the body adjusts to the medication, while others might need medical attention, such as blood clots or vision changes.

It is necessary to take immediate medical care for severe or persistent side effects for severe or persistent side effects.

Individual responses to Estrogen patches can vary. 

Open communication with a healthcare provider is essential.

Frequently Asked Questions

Do Estrogen patches have side effects?

Estrogen patches can have side effects, including skin irritation, breast tenderness, and mood swings. It is also common to observe headaches, nausea, and indigestion while using these patches. It is advisable to discuss potential reactions with a healthcare provider before use.

How long can I stay on Estrogen patches?

The duration for which one can stay on Estrogen patches varies on various factors, including the severity of the condition and how well they respond to the treatment. A doctor determines the appropriate timeframe based on individual needs and health factors. Regular check-ups are essential during extended usage.

Which Estrogen patch has the least side effects?

The Estrogen patch with the least side effects can vary by individual response. Consultation with a doctor helps identify the most suitable option based on medical history and preferences.

How long does it take to feel the effects of Estrogen patch?

The time to feel the effects of an Estrogen patch can differ. Some people notice changes within a few weeks, while others might take a few months. It is important to be consistent and get regular medical follow-ups to help assess progress and adjust treatment if needed.

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