How Long Does it Take for Estradiol Pill to Absorb? A Quick Overview

Nishi Kashyap
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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how long does it take for estradiol pill to absorb

Estradiol is a medication that is used to treat many health issues like menopausal symptoms.

Understanding how long the Estradiol pill takes to be absorbed into the body is important.

This will allow its effects to be addressed and ensure a safe treatment.

In this article, we will explore how long it takes for Estradiol pill to absorb, along with how effective the medication is in treating various health concerns.

We will also inform you how to use the pill and a few precautions while taking this medication.

Time Estradiol pill takes to get absorbed

Estradiol pill or tablet takes seven days to get adjusted to your body. 

 Absorption of the pill also depends on the amount of dose given to the patient.

Medication taken orally by mouth or through injections absorbs comparatively more Estrogen than vaginal tablets.

A study published by The National Library of Medicine evaluated the absorption of Estradiol from vaginal tablets in postmenopausal women.

According to the research, Estrogen levels show low absorption into the body.

Low absorption is considered good because it means the Estrogen mainly stays in the vaginal area and doesn’t cause widespread effects.

The study confirmed that doses of Estradiol worked well in treating vaginal problems without causing harmful effects on the rest of the body.

That is why, for treating menopausal vaginal symptoms, you should use products that are used directly in the vagina.


Effectiveness of Estradiol pill

The effectiveness of the Estradiol pill can differ in individuals. 

A study published by The National Library of Medicine assessed Estradiol’s effectiveness in treating menopausal symptoms.

The research randomly assigned 244 postmenopausal women with moderate to severe hot flashes to receive the medication.

It was concluded from the study that hot flashes of the women who received the medication were significantly reduced.

Another research indicated that Estradiol effectively treats depression in Perimenopause women.

How to use the Estradiol pill

Taking medicine and water glassSource: InkkStudios_from_Getty_Images
Taking medicine

You need to follow a specific procedure on how to use Estradiol.

For mouth pill

Here are some basic things you need to follow:

  • Carefully read all the instructions provided in the medication leaflet
  • As directed by your doctor, take the pill by mouth with or without food
  • You can take it with food or soon after a meal to avoid stomach upset
Do not take the medicine without consulting with your doctor. If you fear consuming too much of this medication, go to the emergency room or call a poison control

For vaginal tablet

Here are a few things to remember before using an Estradiol tablet for treating vaginal symptoms of Menopause.

  • Take vaginal tablets during bedtime unless your doctor directs otherwise.
  • This tablet is only meant for use in the vagina, not by mouth
  • Before and after use, wash and dry your hands
  • Follow the package directions carefully
  • Use a new applicator for each dose, and use it at the same time every day
  • Lie on your back, bend your knees, and gently insert the applicator into the vagina
  • Press the plunger until fully depressed to release the tablet into the vagina
  • Remove the applicator gently after use and throw it away

Only use the medication as directed. Do not use it more often than prescribed.

Dosage of Estradiol pill

The Estradiol pill or tablet dosage depends on the specific condition they are being treated. 

Make sure you follow the dosage instructions your healthcare provider provides. 

Here are some general recommendations on the oral dosage form of Estradiol suggested by the Mayo Clinic.

  • For breast cancer in men and women after menopause:
    Adults- 10 mg 3 times a day for at least three months
  • For treating genital skin problems, vaginal inflammation, and ovary-related problems:
    Adults- 1 to 2 mg per day for at least three months
  • For preventing loss of bones (Osteoporosis):
    Adults- 0.5mg a day
  • For treating Prostate Cancer
    Adults- 1 to 2 mg three times a day
  • For treating Prostate Cancer
    Adults- 1 to 2 mg three times a day

Doctors may prescribe a daily dosing schedule or specify taking medicine on certain days of the month. 

They may also adjust the dose based on your response to the medication.

Precautions while taking the Estradiol pill

There are a few precautions that you must consider while taking the Estradiol pill.

  • Regular visits are essential with your doctor to assess your progress. They will diagnose if the medication is working correctly and check for any unwanted side effects
  • Using Estradiol during pregnancy can harm the unborn baby. If you suspect pregnancy while taking the drug, inform your doctor immediately
  • Opt for medical care if you face symptoms like confusion, trouble speaking, double vision, headaches, or weakness in limbs or facial muscles
  • Take your doctor’s help if you experience any allergic reaction due to Estradiol, like rash, swelling of hands, and itching
  • Report any abnormal vaginal bleeding or unusual changes to your doctor immediately
Estrogen alone or combined with Progestin should not to be used to prevent cardiovascular diseases.


Estradiol taken by mouth absorbs more Estrogen than Estradiol vaginal tablets.

These pills take some time to dissolve in the body.

Estradiol is effective in treating symptoms of Menopause and depression among Perimenopause women.

You should follow the instructions provided in the leaflet and given by your doctor for proper usage and dosage of the Estradiol pill.

Do not take the drug more than prescribed.

You can effectively manage your health conditions by following precautions like regular checkup visits.

Frequently Asked Questions

How long it takes for an Estradiol pill to get absorbed?

Estradiol pill takes some time to get absorbed. Pills taken by mouth or through injections are absorbed more compared to vaginal tablets. Vaginal tablets have low absorption, mainly staying in the vaginal area.

Is Estradiol effective in treating menopausal symptoms?

Yes, Estradiol is effective in treating menopausal symptoms like hot flashes and depression. Research shows it can significantly reduce hot flashes and improve mood in women during Menopause.

How to use Estradiol vaginal tablet?

For using Estradiol vaginal tablet, follow the mentioned steps. Wash hands before use, follow package instructions, use a new applicator for each dose, gently insert into the vagina, press the plunger, and remove the applicator after use.

What precautions are needed while having Estradiol medication?

Regularly visit your doctor for monitoring, avoid using Estradiol during pregnancy, seek medical help for allergic reactions, and report any unusual bleeding or changes immediately. Follow the prescribed dosage and usage instructions carefully

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