Antibiotics for UTI in Pregnancy: Safeguarding Maternal Health

Manish Choudhary
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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antibiotics for uti in pregnancy

Urinary Tract Infections (UTIs) are a common concern during pregnancy, affecting both the health of the mother and the developing fetus. 

While UTIs are generally treated with antibiotics, the unique context of pregnancy calls for careful consideration of treatment options.

In this article, our focus will be on understanding the safety of antibiotics for UTI in pregnancy and those that should be avoided during pregnancy. 

We will also delve into the essential precautions that pregnant individuals need to consider to ensure the well-being of both themselves and their babies.

Safe antibiotics for UTIs during pregnancy

UTIs during pregnancy can be concerning.

The good news is that many antibiotics are safe to use during this time. 

Here are the antibiotics considered safe during pregnancy:


Penicillin antibiotics, such as Ampicillin and Penicillin G, are considered secure options for treating UTIs during pregnancy. 

They are often prescribed when the bacteria causing the infection can be treated effectively with penicillin.

The use of Penicillin antibiotics has been associated with a low risk of adverse effects on the developing fetus.


Cephalexin (Keflex) is another antibiotic for UTIs during pregnancy. 

It is generally safe and can be taken 2 to 4 times daily for 3 to 7 days. 

Other Cephalosporins like Cefuroxime and Cefpodoxime may also be used.


Erythromycin, a macrolide antibiotic, is often considered safe for use during pregnancy. 

It is commonly prescribed when other antibiotics are not suitable or when there are concerns about Penicillin allergies.

Erythromycin can effectively treat UTIs caused by susceptible bacteria and is used as an alternative option in pregnant individuals.


Fosfomycin is an antibiotic that may be considered for treating UTIs during pregnancy. 

It is typically prescribed as a single-dose therapy and is generally considered safe, with limited systemic absorption, reducing the potential risk to the fetus.


Amoxicillin, a broad-spectrum antibiotic, is generally considered safe during pregnancy.

It is often prescribed when other antibiotics are not suitable or when the benefits outweigh potential risks.

Amoxicillin is effective in addressing UTIs caused by bacteria that are responsive to its treatment, and it provides a favorable safety profile for pregnant individuals.

It’s crucial to complete your prescribed antibiotic course to prevent future infections that may become resistant to common UTI medications.

AntibioticRecommended dosageEstimated time
PenicillinDosage varies by specific typeTypically 7-10 days
Cephalexin250 mg two or four times dailyUsually 3-7 days
Erythromycin250 to 500 mg four times dailyTypically 7-10 days
FosfomycinOne 3-g sachet
Single-dose treatment
AmoxicillinDosage varies by specific typeTypically 7-10 days

Antibiotics to avoid during pregnancy

some antibiotics should be avoided during pregnancySource: gee1999 from Getty Images
Consult a doctor before taking antibiotics

While many antibiotics are safe, some should be avoided during pregnancy or used only at specific times:


This antibiotic may be prescribed during pregnancy, but it’s not entirely safe during the first trimester. 

It’s best to avoid it in early pregnancy unless there are no other options. 

It can be used safely in the second and most of the third trimester but should be avoided at the end of pregnancy as it may raise the risk of infant Jaundice.


This antibiotic has conflicting safety data in the first trimester. 

It’s typically avoided during pregnancy unless there are no alternatives. 

It should also be avoided at the end of pregnancy, as it can cause severe infant Jaundice.


Antibiotics like Ciprofloxacin and Levofloxacin are used for UTIs in non-pregnant individuals.

However, these antibiotics are generally avoided during pregnancy because of their potential to cause birth defects. 

In cases where no other options are available, alternative approaches for UTI treatment may be considered. While antibiotics are typically necessary for UTIs during pregnancy, Phenazopyridine (AZO) can help ease discomfort from symptoms like burning, frequency, and urgency. Always consult a healthcare provider for guidance.

Precautions and preventive measures

Drink plenty of waterSource: LittleBee80_from_Getty_Images
Drink plenty of water

Consider the following practical steps to minimize your risk of UTIs during pregnancy:

  • Stay hydrated: Staying well-hydrated aids in the elimination of bacteria from the urinary system
  • Maintain a healthy diet: A balanced diet supports overall health, including urinary tract health
  • Limit caffeine and sugar: High consumption of caffeine and sugar can increase the risk of UTIs
  • Avoid alcohol: Alcohol can irritate the bladder and worsen UTI symptoms
  • Urinate promptly: Don’t delay urination when you feel the need
  • Empty bladder completely: Ensure your bladder is fully emptied each time you urinate
  • Urinate before and after sex: This can help prevent bacteria from entering the urinary tract
  • Maintain genital hygiene: Keeping the genital area clean reduces the risk of infection
  • Wipe front to back: Proper wiping after using the bathroom prevents the spread of bacteria
  • Wear comfortable clothing: Avoid tight-fitting pants and opt for breathable fabrics like cotton
  • Don’t soak for extended periods: Limit time spent in baths to prevent moisture-related issues
When considering antibiotics for UTIs during pregnancy, always consult with a healthcare provider to ensure both maternal and fetal safety.


Antibiotics for UTI in pregnancy require careful management to avoid complications.

Safe antibiotic choices like Penicillins and Cephalosporins are effective against UTIs without posing significant risks to the fetus. 

However, certain antibiotics like Nitrofurantoin and Fluoroquinolones should be used cautiously or avoided altogether. 

Preventive measures, including maintaining good hygiene and staying hydrated, can help reduce the risk of UTIs. 

It’s essential to seek guidance and treatment from your healthcare provider during pregnancy for proper care.

Recommended Article
To learn about effective UTI treatments during pregnancy, read UTI in Pregnancy Treatment: Effective Strategies for a Healthy Mother and Baby.

Frequently Asked Questions

Can untreated UTIs harm my baby during pregnancy?

Neglecting to address UTIs promptly can result in heightened risks of severe complications, including premature labor and reduced birth weight. If you have any suspicions of a UTI, it is crucial to seek immediate medical attention.

Are all antibiotics safe to use during pregnancy?

Not all antibiotics are safe during pregnancy. Healthcare providers carefully select antibiotics that are known to have minimal risk to the developing fetus. Always consult your doctor before taking any medication during pregnancy.

What antibiotic is safe for pregnancy UTI?

Antibiotics like Amoxicillin, Erythromycin, and Cephalexin are often considered safe for treating UTIs during pregnancy. Nevertheless, it is vital to seek guidance from your healthcare professional to determine the most suitable and secure option for you.

What is the first-line treatment for UTI in pregnancy?

The first-line treatment for UTIs in pregnancy often includes antibiotics such as Amoxicillin, Nitrofurantoin, or Cephalexin. Your healthcare professional will ascertain the most appropriate choice per your circumstances.

Can I continue to take antibiotics for UTIs in the third trimester of pregnancy?

The use of antibiotics in the third trimester should be discussed with your healthcare provider. Some antibiotics, like Nitrofurantoin, may be avoided near term to prevent certain complications.

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