What Medications Interfere With Birth Control Pills: A Comprehensive Guide

Maanvi Kashyap
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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what medications interfere with birth control pills

Ensuring the efficacy of birth control pills is crucial for those relying on oral contraceptives as their chosen method of preventing pregnancy. 

While birth control pills are about 99% effective, certain medications and supplements can interfere with their reliability, potentially leading to unintended pregnancies.

Understanding the potential interactions between medications and birth control pills is essential for individuals seeking effective contraception. 

In this article, we will focus on what medications interfere with birth control pills.

Medications that interfere with birth control pills

Birth control pills, when taken consistently and correctly, are highly effective in preventing pregnancy. 

However, the interaction between oral contraceptives and other medications can compromise their efficacy. 

Let’s delve into the medications that have the potential to interfere with birth control pills:


Various antibiotics in packetsSource: Denisfilm_From_Getty_Images
Various antibiotics in packets

While the belief that all antibiotics interfere with birth control pills is a common misconception, it’s essential to note that certain antibiotics can affect contraceptive efficacy. 

Rifampin, used to treat Tuberculosis, is known for its potential to reduce the effectiveness of hormonal contraceptives.

It is advisable to use alternative contraceptive methods during antibiotic treatment and for a short time afterward.

Besides preventing pregnancy, birth control pills were initially developed to treat menstrual disorders, with their contraceptive effects discovered during clinical trials. This pivotal discovery revolutionized women’s health and reproductive rights.

Antiepileptic drugs

Medications used to manage seizures, such as Phenytoin, Carbamazepine, and Phenobarbital, may reduce the effectiveness of birth control pills. 

Women taking antiepileptic should consult their healthcare provider to explore alternative contraceptive options.


Some antifungal medications, particularly those containing Griseofulvin, may interfere with birth control pills. 

Women prescribed antifungals should discuss contraceptive alternatives with their healthcare provider to ensure optimal protection against unintended pregnancies.

Antiretroviral drugs

Antiretroviral medications like Darunavir, Efavirenz, Lopinavir/Ritonavir, and Nevirapine may interfere with birth control pills. 

Women with HIV should get a better understanding of the contraceptive methods that align with their overall health needs.


Modafinil can reduce the effectiveness of certain contraceptives, increasing the risk of pregnancy

Additionally, using Modafinil while planning to become pregnant can lead to birth defects in the unborn child. 

It is crucial to avoid using Modafinil if pregnancy is in your plans.

St. John’s Wort

The herbal supplement St. John’s Wort, commonly used for mood disorders like depression, may decrease the effectiveness of birth control pills.  

Using this medication along with birth control pills is not recommended.

Recommended Article
Learn about non-hormonal birth control methods to see if they are suitable for your preference.
Read Exploring Non-Hormonal Birth Control Options: A Comprehensive Guide to know more.

Supplements that affect birth control pills

vitaminsSource: ready made from Pexels
Various vitamin tablet

In addition to medications, certain supplements can also impact the efficacy of birth control pills. 

Understanding these interactions is crucial for individuals seeking reliable contraception while incorporating supplements into their health regimen:

Vitamin C

High doses of vitamin C, also known as Ascorbic acid, may increase Estrogen levels when using birth control pills. 

While moderate vitamin C intake from a balanced diet is generally safe, individuals taking vitamin C supplements in excess should be cautious. 

It’s advisable to assess potential interactions and explore suitable contraceptive alternatives.

Vitamin B12

There’s no evidence that B vitamins interfere with birth control. 

However, taking birth control pills can deplete B12 levels, so consulting your doctor about supplementation might be beneficial.


Birth control pills rely on consistent use, but some medications and supplements can mess with their effectiveness. 

Antibiotics like Rifampin, seizure medications like Phenytoin, antifungals with Griseofulvin, HIV meds like Darunavir, Modafinil, and herbs like St. John’s Wort can all lower the efficacy of one or both medications.

Moreover, an excess of vitamin C in high doses may have an effect on birth control, and it’s worth noting that birth control use can lead to a reduction in B12 levels.

Consultation with healthcare providers is crucial for understanding birth control, empowering individuals to make informed choices, and ensuring reliable family planning.

The effectiveness of your birth control pills can be compromised by certain medications and supplements. Always disclose all medications and supplements you take to your healthcare provider to ensure reliable contraception and avoid unintended pregnancy.

Frequently Asked Questions

Do any drugs affect birth control?

Certain drugs, including some antibiotics and anticonvulsants, may potentially interfere with the effectiveness of birth control pills. Consult with your healthcare provider to discuss specific medications and their impact on contraception.

Can Bactrim interfere with birth control pills?

There is limited evidence suggesting that Bactrim, an antibiotic, may interfere with the effectiveness of birth control pills. It is advisable to use alternative contraception methods during Bactrim treatment and consult with a healthcare professional for personalized guidance.

Does Paracetamol affect birth control pills?

Limited evidence suggests that Paracetamol, when used as directed, doesn’t significantly impact the effectiveness of birth control pills. However, individual responses may vary, and it’s advisable to consult with a healthcare professional for personalized guidance.

Is it safe to rely solely on birth control pills for contraception?

While birth control pills are highly effective when used correctly, it is advisable to use additional contraceptive methods, such as condoms, to enhance protection against unintended pregnancies.

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