Slynd vs Norethindrone: Choosing Which Contraception

Manish Choudhary
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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slynd vs norethindrone

Choosing the right contraceptive method is a crucial decision that involves considering various factors, from health concerns to personal preferences. 

Here, we will explore the distinctions between two popular contraceptive options: Slynd and Norethindrone. 

Both Norethindrone and Slynd are two prominent options, each with its unique characteristics and applications.

Understanding these birth control pills can empower individuals to make informed decisions about their reproductive health.

Read Slynd vs Norethindrone, shedding light on their active ingredients, mechanisms of action, administration, potential interactions, side effects, and key differences.


Before we get into a detailed understanding of the differences, let’s first take a quick look at the major differences between Slynd vs Norethindrone.

Active ingredientDrospirenoneNorethindrone
Mechanism of actionProgestin-onlyProgestin-only or combined
How to administerOne tablet daily, preferably at the same time(24-day hormonal pills, followed by 4 inert pills)Daily, same time for Progestin-only, as directed for combination pills ( 21 days active pill, followed by 7 days placebo)
Side effectsCommon side effects include nausea, headache, breast tendernessCommon side effects include nausea, headache, breast tenderness
Administration considerationsSuitable for those sensitive to Estrogen; particularly beneficial for breastfeeding mothersDrospirenone raises potassium levels in the blood. If you have kidney, liver, or adrenal disease, avoid taking Slynd, as it may lead to severe heart issues and other health problems.

About Slynd and Norethindrone

Here is a comprehensive distinction between Slynd vs Norethindrone:


Slynd is a Progestin-only contraceptive pill that contains Drospirenone as its active ingredient. 

Progestin-only pills are often recommended for individuals who cannot tolerate Estrogen or for breastfeeding mothers. 

Slynd works by suppressing ovulation, thickening cervical mucus, and altering the uterine lining, providing an effective contraceptive method.

Slynd is the first and only Progestin-only pill to contain Drospirenone, offering a unique hormonal contraceptive option for individuals seeking effective birth control without Estrogen.


Norethindrone, on the other hand, is a versatile Progestin.

It is used in various hormonal contraceptives, including Progestin-only pills and combination birth control pills. 

Its mechanism of action is similar to Slynd, inhibiting ovulation, thickening cervical mucus, and altering the uterine lining. 

Norethindrone is suitable for those who prefer a combination contraceptive with both Estrogen and Progestin or those who may need a Progestin-only option.

Key differences

Here are the key differences between Slynd and Norethindrone:

Active ingredient

Slynd: Slynd is the brand name of a contraceptive pill. 

Its active ingredient is Drospirenone, which is a Progestin and antiandrogen medication, making it a Progestin-only contraceptive.

Norethindrone: Norethindrone, on the other hand, belongs to a class of medications known as Progestin.

It is found in both Progestin-only pills and combination birth control pills.


Menstrual Calendar(marked with heart shape)Source: shironagasukujira_from_Getty_Images
Regular menstrual cycle

Slynd: Progestin-only oral contraceptives are highly effective in preventing pregnancy. 

It’s important to note that they do not protect against the transmission of Human Immunodeficiency Virus (HIV) and other Sexually Transmitted Diseases.

Norethindrone: Norethindrone is used in treating Endometriosis, a condition causing pain and irregular menstruation due to the growth of uterine tissue outside the uterus. 

It addresses abnormal periods and induces a regular menstrual cycle in women who previously had regular periods but haven’t menstruated for at least three months, excluding pregnancy or menopause.

As a Progestin medication, Norethindrone inhibits uterine lining growth and prompts hormone production to achieve these therapeutic effects.


Slynd: Slynd has 4 mg of Drospirenone, a higher dose compared to what’s in Combination Oral Contraceptives (COCs). 

Drospirenone, similar to Spironolactone, acts against minerals and has a long half-life of 25–30 hours.

Norethindrone: Norethindrone, the main metabolite, disappears from the plasma with an average half-life of 8 hours.

Mechanism of action

Slynd: Slynd’s mechanism of action revolves around Progestin-only effects, including ovulation inhibition and changes in cervical mucus and uterine lining.

Norethindrone: Norethindrone shares a similar mechanism of action, acting as a Progestin to achieve contraception through the inhibition of ovulation and alteration of cervical mucus and the uterine lining.

How to use

Slynd: Slynd is taken orally once daily at the same time, requiring consistency for optimal effectiveness. 

Take one tablet every day for 28 days. 

During the first 24 days, take one white active tablet daily, and during the next 4 days, take one green inactive tablet daily. 

Make sure to take the tablets at the same time every day, maintaining a 24-hour interval between doses. 

Norethindrone: Similar to Slynd, Norethindrone is taken orally once daily at the same time.

One tablet is taken at the same time each day for 28 days.

Side effects

Slynd: Common side effects of Slynd include nausea, headache, and breast tenderness, but individual responses may vary.

Norethindrone: Similar to Slynd, Norethindrone may commonly cause side effects such as frequent and irregular bleeding and menstrual changes with variations among individuals.

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How to choose

Woman taking consultation from a doctorSource: Getty_images
Woman taking consultation from a doctor

Choosing between Slynd vs Norethindrone involves considering various factors tailored to individual needs and preferences:

  • Health considerations: Consider any pre-existing health conditions and consult with a healthcare provider to ensure the chosen contraceptive aligns with your health profile
  • Sensitivity to Estrogen: If you are sensitive to Estrogen or breastfeeding, Slynd may be a more suitable option due to its progestin-only composition
  • Administration preferences: Evaluate your preference for daily administration. Both Slynd and Norethindrone are oral contraceptives, but individual preferences may influence the choice
  • Medical interactions: Be aware of any potential interactions with other medications you may be taking. Consult with a healthcare provider to ensure compatibility
  • Side effects: Consider your tolerance for potential side effects and discuss any concerns with your healthcare provider
  • Versatility: If you are open to a versatile contraceptive option, Norethindrone, available in both Progestin-only and combination forms, may provide more choices


Norethindrone and Slynd offer distinct contraceptive options, each with unique characteristics. 

Slynd is the brand name of a Progestin-only pill containing Drospirenone, which suits those sensitive to Estrogen or breastfeeding. 

Norethindrone, a versatile Progestin found in various contraceptives, provides options for both Progestin-only and combination pills. 

Slynd, with Drospirenone as its active ingredient, serves as a progestin-only option ideal for those sensitive to Estrogen or breastfeeding. 

Norethindrone, a versatile Progestin, caters to diverse preferences, available in both progestin-only and combination forms. 

Choosing between them involves weighing factors such as health considerations, sensitivity to Estrogen, administration preferences, medical interactions, versatility, and individual tolerance for side effects.

Empowering individuals to make informed decisions about their reproductive health, this guide sheds light on the nuanced differences between these contraceptive options.

Be aware of potential side effects such as nausea and headache while using Norethindrone. Individual responses may vary; consult your healthcare provider if concerns arise.

Frequently Asked Questions

What is the main difference between Slynd and Norethindrone?

The main difference lies in their formulations. Slynd contains Drospirenone, a synthetic form of Progesterone, while Norethindrone is a Progestin-only pil, also used in combination pills. Slynd is designed to minimize side effects, providing a modern and well-tolerated contraceptive option.

Can I use Slynd or Norethindrone if I smoke?

Slynd may not be suitable for women who smoke, especially those over 35, due to potential risks of blood clotting. Norethindrone is generally not considered to raise any such risk for smokers. However, in any case, it is not suggested to smoke as it could be detrimental to your health. 

How do I choose between Slynd and Norethindrone?

The choice between Slynd and Norethindrone depends on individual health factors, preferences, and lifestyle. Consulting with a healthcare professional is essential to make an informed decision aligned with your specific needs.

Are there alternative contraceptive options to Slynd and Norethindrone?

Yes, there are various contraceptive options, including combined hormonal contraceptives, Intrauterine Devices (IUDs), and barrier methods. Each option has its advantages and considerations, and the best choice depends on individual preferences and health factors.

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