Knowing the HIV Pain Areas & Different Causes Behind Them

Monali Sharma
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

Published On:

hiv pain areas

In 2022, 1.3 million individuals became newly infected with HIV.

Living with HIV brings challenges, and among them, managing pain becomes a critical aspect of overall well-being.

There can be nerve damage, leading to pain, tingling, or numbness, typically in the hands and feet.

There might be inflammation in muscles and joints.

Effective pain management is very important to improve the quality of life for those with HIV.

This article helps to understand what leads to HIV pain areas in the body, the various types of causes, and how to manage the pain.

Types of HIV pain

woman having cramping pain in the backSource: Staras_from_Getty Images
HIV back pain

HIV-related pain can affect various parts of the body and is a common concern for individuals living with HIV. 

Some common types of pain associated with HIV include:

  • Peripheral Neuropathy: Pain due to nerve damage, mostly in the feet and hands. It may be described as numbness, tingling, or burning. Nerve damage can be caused by HIV itself, HIV drugs, or other medical conditions such as Diabetes
  • Abdominal pain: There are various potential reasons for abdominal pain, including as a side effect of some HIV drugs
  • HIV back pain: Another prevalent type of pain reported by individuals living with HIV is backache. In addition to HIV-induced Peripheral Neuropathy, other possible causes of HIV-related back pain include increased inflammation and exaggerated immune system responses, and Antiretroviral treatment
  • Headache: A common type of pain among people living with HIV, which can range from mild to severe and may be caused by low CD4 cell counts, infections, or other HIV-related illnesses
Recommended Article
HIV-related headaches can occur at any stage of the infection, including during the incubation phase, in people with symptomatic HIV-1 infection, and following an AIDS-defining illness.To know about symptoms, causes, and treatment of HIV-related headaches, read:
HIV Headache: Unveiling Its Causes and Treatment Options
  • HIV joint pain: About 5% of HIV-positive patients experience pain and inflammation in joints or soft tissues due to HIV infection. They may have rheumatic diseases like Myositis, Osteomyelitis, Psoriatic arthritis, Fibromyalgia, Vasculitis, and others
  • HIV pain in legs: HIV-related pain in the legs can be due to various factors, including HIV-induced peripheral neuropathy, as has been mentioned above. Other possible causes of HIV-related leg pain include HIV-related Arthritis, muscle pain, Fibromyalgia, and side effects of HIV medications

The exact causes of HIV-related pain are not fully established. 

Still, it may be a symptom of HIV itself, a result of opportunistic infections, a side effect of antiretroviral drugs, or concurrent neoplasia.

Some of these causes have been discussed in the next segment.

HIV-related chronic pain is a significant issue for people living with HIV (PLWH), with prevalence estimates ranging from 25% to 85%.

Causes of HIV pain

The prevalence of pain in PLWH (People Living With HIV)  varies depending on factors such as the stage of disease, care setting, and study methodology.

Pain in PLWH can be categorized into several types:

  • Direct pain: HIV infection itself causes direct pain in PLWHA. This results from the virus affecting the peripheral or central nervous system
  • Immune suppression-related pain: Chronic pain is a significant problem in people living with HIV (PLWH), and the immune system is crucial in the development and maintenance of pain. In many cases of chronic pain, there is an increase in the circulating pro-inflammatory Cytokines in the blood, possibly due to an immune response, that leads to immune-related pain
  • Antiretroviral Treatment (ART)-related pain: This pain arises as a side effect of ART medications. Some ART medications, particularly nucleoside analogues and protease inhibitors, can cause mitochondrial damage and nerve damage, leading to neuropathy
  • Idiopathic pain: Idiopathic pain in HIV patients refers to pain that does not have a clear cause or etiology. This type of pain can be challenging to diagnose and manage

Pain due to other illnesses

There can be HIV pain areas not directly related to HIV or its treatment. 

These other types and causes of HIV pain include:

  • Depression, anxiety, and stigma related to HIV: The stigma associated with HIV, as well as the high prevalence of depression and anxiety, can negatively modify pain perception and management in PLWHA
  • Chronic inflammation: Chronic inflammation caused by the virus can lead to central sensitization, contributing to the development of chronic pain in people living with HIV
Don’t indulge in substance abuse to deal with HIV. Substance abuse can interact with the stigma due to HIV and chronic pain, compromising health-promoting behaviors and exacerbating pain.

Managing HIV-related pain

Yoga can help to manage painSource: Cliff_Booth_from_Pexels
Yoga can help to manage pain

Effective management of HIV-related pain involves a multidimensional approach, including:

  • Pharmacological interventions: Use of medications, like anticonvulsants, antidepressants, and capsaicin cream to alleviate pain
  • Non-pharmacological interventions: Techniques such as CBT, acupuncture, and massage to help manage pain
  • Psychosocial support: Addressing depression, anxiety, and stigma related to HIV to improve pain management
  • Regular screening and monitoring: Regular assessment of pain prevalence, severity, and subjective experiences in PLWHA

Consultation with a medical expert is essential to tailor an individualized pain management plan.


Chronic pain is a significant issue for PLWHA, with a wide range of prevalence rates reported.

Understanding the different types of pain like abdominal pain, joint pain, back pain, and headache and their causes is essential for developing effective management strategies. 

The causes can be directly associated with the virus or its treatment, among other things.

Effective management of HIV-related pain involves a multidimensional approach, including pharmacological interventions, non-pharmacological interventions, psychosocial support, and regular screening and monitoring.

By addressing the various factors contributing to HIV-related pain, healthcare professionals can help improve the quality of life and function of people living with HIV.

Frequently Asked Questions

What is the prevalence of chronic pain in people living with HIV?

The prevalence of chronic pain in people living with HIV (PLWH) is reported to be high, with estimates ranging from 25% to 90%. Various factors, including HIV-related neuropathy and other comorbidities, contribute to the complex nature of pain in this population.

Can HIV medications cause pain?

Yes, some HIV medications can cause side effects, including pain. These may include joint pain, muscle pain, or neuropathy. Individuals on HIV medications need to communicate any discomfort with their healthcare provider for proper management.

What are the different types of pain experienced by people living with HIV?

People with HIV may experience various types of pain, including neuropathic pain resulting from nerve damage, musculoskeletal pain affecting muscles and joints, and psychological pain associated with stigma. Pain management is vital for improving their quality of life.

How can one manage the emotional pain associated with HIV?

Coping with emotional pain from HIV involves seeking support from loved ones or support groups, counseling, practicing self-compassion, and adhering to medical treatments. Open communication, education, and focus on overall well-being contribute to emotional resilience and improved quality of life.

WowRxPharmacy uses only high-quality sources while writing our articles. Please read our content information policy to know more about how we keep our content reliable and trustworthy.

More Articles Like This

Leave a Comment

Receive the latest articles in your inbox!