Are you taking Lisinopril or Cialis together? 

If you are, then understanding the potential interactions between these two medications is vital. 

Lisinopril is used to manage Hypertension, while Cialis is prescribed for ED . 

Using them together can potentially affect your blood pressure vitals as well as can lead to potential side effects. 

This article aims to provide insights into the possible interactions between Lisinopril and Cialis,and risks to look out for individuals taking Lisinopril. 

Lisinopril and Cialis: Overview

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Cialis pills on black background

Cialis, a widely prescribed treatment for ED in men, contains Tadalafil, a PDE-5 inhibitor. 

It elevates cyclic Guanosine Monophosphate (cGMP) levels by inhibiting the PDE5 enzyme, enhancing penile blood flow, and facilitating erections. 

On the other hand, Lisinopril, an Angiotensin-Converting Enzyme (ACE) inhibitor, is used to manage high blood pressure and heart conditions.

Its mechanism involves relaxing blood vessels, facilitating the heart’s blood-pumping process, and decreasing blood pressure.

Despite their differing functions, both drugs can affect blood pressure, potentially leading to simultaneous interactions.

Research has demonstrated that PDE-5 inhibitors are considered safe for individuals receiving treatment for Hypertension.

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Can you take Lisinopril and Cialis together

Around 67-68% of men with high blood pressure (Hypertension) experience some form of ED .

Notably, men with ED have a higher likelihood of having Hypertension. 

PDE5 inhibitors effectively treat ED in men with Hypertension, even those on various blood pressure medications. 

Combined with common blood pressure medicines like Lisinopril, PDE5 inhibitors usually result in minimal or no additional blood pressure reduction.

Moreover, this combination doesn’t significantly increase the risk of harmful side effects. 

Furthermore, when examining data from large-scale clinical trials, there wasn’t a noticeable difference in side effects between those taking Tadalafil with or without blood pressure meds. 

If someone is on blood pressure drugs and takes a 20 mg dose of Tadalafil, there might be a small drop in blood pressure, but it’s generally minor and not concerning.

However, caution is advised for patients on alpha blockers, used for Hypertension or an enlarged prostate, as these individuals may experience a sudden drop in blood pressure upon standing.

It’s essential to note that those taking organic Nitrates should avoid PDE5 inhibitors due to a risk of severe blood pressure drop when used together.

Fact
Due to its longer duration of action, Tadalafil is likely the preferred PDE-5 inhibitor for blood pressure management. A daily low dose of Tadalafil (5 mg) can enhance blood pressure control and erectile function.

Risks and considerations

PDE5 inhibitors are typically regarded as safe when taken alongside antihypertensive medications. 

Nevertheless, it’s important to note that the PDE5 enzyme is also present in the blood vessels throughout the body.

Thus, inhibiting it may lead to the widening of the systemic blood vessels, potentially causing vasodilation.

A recent study conducted aimed to examine the frequency of hypotension-related side effects in patients who were simultaneously prescribed Tadalafil and Anti-Hypertensive Medication. 

The most frequently used AHMs were Angiotensin-Converting-Enzyme (ACE) inhibitors in ED studies.

The study suggests that the simultaneous use of Tadalafil and AHM does not significantly increase the risk of hypotension-related issues in patients with ED or BPH. 

However, it’s important for healthcare providers to carefully assess and monitor patients, especially those with underlying cardiovascular conditions when prescribing Tadalafil and AHM to ensure patient safety.

Warning
Consult your doctor regarding the consumption of grapefruit or grapefruit juice while taking Cialis. The reason being grapefruit contains enzymes that affect the metabolism of Tadalafil in body hence, can lead to unwanted side effects like increased blood pressure. 

Takeaway

The combination of Cialis (Tadalafil) and Lisinopril is generally safe and effective for individuals with both ED and Hypertension.

Research suggests that PDE5 inhibitors, particularly Tadalafil, can benefit blood pressure management while addressing ED. 

However, caution is advised for those on alpha blockers or organic Nitrates due to potential blood pressure fluctuations.

Moreover, alternative options for ED treatment exist, including Viagra non-medical approaches like Vacuum Erection Devices and Penile Rehabilitation Therapy.

Consulting a healthcare provider is crucial to determine the most suitable treatment, considering individual health conditions and medication history.

Ultimately, with proper medical guidance, individuals can find an effective solution that addresses both ED and Hypertension while prioritizing their overall well-being.

Frequently Asked Questions

Can you take Tadalafil with blood pressure medication?

Yes, you can take Tadalafil with certain blood pressure medications, but it’s crucial to do so under the guidance of a healthcare provider. Tadalafil can cause blood vessels to widen, and when combined with certain antihypertensive medications, it may lead to a significant drop in blood pressure.

What should you not mix Cialis with? 

Do not mix Cialis with Nitrate medications (e.g., Nitroglycerin), recreational drugs called “poppers” (Amyl Nitrate), or Alpha-blockers (unless directed by a healthcare provider). Combining these substances with Cialis can lead to severe drops in blood pressure, which may result in dizziness, fainting, or other dangerous health complications.

Does Cialis increase BP? 

Cialis (Tadalafil) can cause changes in blood pressure, including both high and low blood pressure. While high blood pressure is less common, both scenarios are possible side effects. You must monitor your blood pressure and consult a healthcare provider if you experience significant changes or adverse reactions while taking Cialis.

When should I avoid Cialis?

Cialis should be avoided by individuals who have experienced recent heart attacks or strokes, suffer from angina (chest pain), heart failure, uncontrolled high blood pressure or irregular heartbeats, severe liver disease, or retinal eye problems. This medication has not been studied in these patient groups and is not recommended for them.

What is the best way to take Cialis for maximum effect? 

For optimal results, you can take Cialis either daily at a consistent time or as needed, ideally 30 minutes to two hours before engaging in sexual activity. Cialis can remain effective for several hours and remains in your body for approximately 36 hours.

Citations:
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