Unveiling the Mechanism: How Does Cialis Work to Treat ED?
Cialis is a brand name for Tadalafil that treats Erectile Dysfunction (ED) and Benign Prostatic Hyperplasia (BPH) in men.
Cialis is FDA-approved for treating sexual dysfunction and prostate enlargement in men.
But how does Cialis work that makes it the best choice for treating these conditions?
In this article, we will uncover the action mechanism of Cialis and how it works to be a better choice for people with ED.
So, let’s delve into the topic and explore it in detail!
How does Cialis work to treat ED
Cialis falls in the Phosphodiesterase type 5 inhibitors category and can improve erection in people with ED.
Cialis is one of the most prescribed ED medicines and received US FDA approval to combat ED in 2003.
The working of the Cialis can be understood by the mechanism of erection in the presence and absence of Cialis:
Normal physiology of erection
On sexual stimulation, Nitric Oxide (NO) is released in the penis.
It activates an enzyme, Guanylate Cyclase, which further increases the level of cyclic Guanosine Monophosphate (cGMP).
The increased cGMP increases the arterial relaxation in the penis. It enhances the blood influx to the penis that causes erection.
Cialis action of mechanism
Cialis inhibits the PDE5 enzyme that degrades cGMP and is responsible for interrupting the relaxation of penile smooth muscles and blood vessels.
As Cialis inhibits PDE5, the level of cGMP increases and promotes more blood to flow to the penis, causing erection.
Moreover, Cialis does not cure ED. Rather, it treats the symptoms of impotence in men.
Cialis does not prevent pregnancy and transmission of Sexually Transmitted Diseases.
How long does it take for Cialis to work
After ingesting Cialis, it can take as early as 15 minutes to two hours for the onset of the drug action.
Tadalafil has an action duration of up to 36 hours after ingestion.
It means that on getting sexual stimulation, you can achieve an erection for 36 hours.
How to make Cialis work faster
There is no direct way to make Cialis work faster.
However, you can avoid the reduced absorption of the drug for better results in the following ways:
- Take Cialis at least 30 minutes before sexual intercourse
- Avoid consuming high-fat foods before taking Cialis
- Reduce alcohol consumption
- Do not consume grapefruit or grapefruit juice while taking Cialis
Also, be cautious and consult a healthcare professional before taking the following medications with Cialis:
- Nitrates medicines
- HIV medicines
- Certain antibiotics
- Antiseizure medicines
- Drug metabolism inhibiting drugs
How do you know when Cialis is working
Cialis does not work immediately after taking the pills.
You have to give Cialis at least 30 minutes for the onset of the drug action.
In some people, it can show effects as early as 15 minutes, or it can take up to 2 hours in some people for the onset of drug action.
However, once the mechanism starts, you can notice erectile changes on getting sexually stimulated.
Thus, you can conclude that Cialis is working.
Why is Cialis not working
Though Cialis is an effective medicine, it may take longer to work if it is not administered correctly.
Therefore, Cialis may not be working for you because:
- You are not sexually aroused
- The dosage is not enough for action
- You took Cialis with a heavy-fat meal
- You didn’t give Cialis much time for the onset of action
Conclusion
Cialis is a brand name for the generic medicine Tadalafil, recognized to treat Erectile Dysfunction in men.
The medicine is FDA-approved for the treatment of ED and falls in the PDE5 inhibitors category.
It can inhibit the PDE5 enzyme and enhance the blood influx to the penis to improve erections.
Cialis is an effective medicine and can enable the drug action for up to an impressive 36 hours in men.
You can follow the guidelines to make Cialis work with efficacy. However, it may only work properly if administered correctly.
Therefore, consult a healthcare practitioner to prescribe a dosage for the best results.
Frequently Asked Questions
Is there a downside to taking Cialis?
Yes, there are some downsides to taking Cialis. It can cause side effects such as headache, flushing, indigestion, and muscle aches. Rare serious side effects can include sudden vision loss, hearing problems, and chest pain.
Who should not take Cialis?
People with certain medical conditions like a history of stroke, coronary heart disease, or retinitis pigmentosa should avoid taking Cialis. It can also interact with medications such as nitrates and blood pressure drugs, making it unsafe for those on such treatments.
How does Cialis work to treat ED?
Cialis inhibits the PDE5 enzyme that interrupts the smooth muscle and blood vessel relaxation in the penis. Thus, Cialis can enhance blood flow to the penis and improve erection in men. You should be cautious and consult your doctor before taking Cialis.
How long does Cialis work?
Cialis can work for up to an impressive 36 hours after taking medicine. It means that you can get an erection for up to 36 hours on getting sexual stimulus. However, it can vary from person to person.
How long does Cialis take to work?
Cialis can take up to 30 minutes to initiate drug action. However, some people may notice improvements in their erection within 15 minutes of taking Cialis. In some cases, the medicine can take up to 2 hours to initiate drug action.
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