Is Levofloxacin a Penicillin: Find the Truth

Aarohi Batra
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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is levofloxacin a penicillin

Health is an essential aspect of everyone’s life. But bacterial infections can disrupt and negatively impact the lives of people.

To treat the infection, a healthcare provider can prescribe antibiotics, such as Levofloxacin and others that contain Penicillin.

Levofloxacin is an antibiotic with a broad spectrum and is used to treat the disease caused by bacteria.

On the other hand, Penicillin has always been one of the first conventional medicines to treat various bacterial infections and promote a healthy lifestyle.

But is Levofloxacin also a Penicillin-containing drug? And is it safe to administer if you are sensitive to Penicillin?

Knowing about your drug is necessary.

Therefore, this article will help you understand “Is Levofloxacin a Penicillin” and how can you distinguish these medically approved drugs to treat your infections.

An overview

Before learning about Levofloxacin and Penicillin, let’s take a look at an overview of the distinction between these anti-bacterial drugs:

FeaturesLevofloxacinPenicillin
Drug ClassFluoroquinolonesNatural Penicillin
Brand NameLevaquinN/A
Indicated forBacterial infectionBacterial infections
AdministrationIntravenous solutionOral tabletOral solutionDeep intramuscular injection
Mode of ActionInhibits bacterial DNA synthesisInhibits the Transpeptidase enzyme

Is Levofloxacin a Penicillin

Levofloxacin is not a PenicillinSource: yourstockbank_from_Getty_Images
Levofloxacin is not a Penicillin

The answer is no, Levofloxacin is not a Penicillin.

Levofloxacin is a third-generation Fluoroquinolone antibiotic used to treat bacterial infections. 

The antibiotic was patented in 1987 and subsequently received FDA approval in 1996.

Levofloxacin can be used to treat the following medical conditions:

  • Community-Acquired Pneumonia (CAP)
  • Complicated and Uncomplicated skin structure infections
  • Chronic bacterial Prostatitis
  • Urinary Tract Infections (UTIs)
  • Acute Pyelonephritis
  • Anthrax
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On the other hand, the Penicillin family of antibiotics also has bactericidal (kills bacteria) activity, with excellent distribution throughout the body and low toxicity.

Penicillin is in the beta-lactam antibiotic class of drugs. It is effective against many different infections, including Gram-positive and Gram-negative bacteria.

However, some bacteria have obtained Penicillin resistance and are now treated with a combination of other drugs, such as in the case of Community-Acquired Pneumonia (CAP).

According to NCBI, to treat CAP, Penicillins were included. 

But as the Penicillin resistance concern grew, Levofloxacin with lower drug resistance was adopted for the treatment. 

Still, Penicillins are used to treat various bacterial infections such as:

  • Pneumonia
  • Enterococcal and non-enterococcal Endocarditis
  • Diphtheria
  • Anthrax
  • Meningitis
  • Syphilis

Does Levofloxacin have Penicillin in it

As Levofloxacin belongs to another class of drugs, it does not have Penicillin in it.

Not only Levofloxacin but all the other drugs in the Fluoroquinolone class lack Penicillin.

Therefore, people sensitive to Penicillin can take Levofloxacin to treat their bacterial infections with much efficacy and low risks of drug resistance.

Warning:
Levofloxacin should be used with a doctor’s prescription and caution in patients with conditions such as Colitis, kidney stones, and central nervous system disorders.

Can you take Levofloxacin if allergic to Penicillin

People suffering from bacterial infections can take LevofloxacinSource: freepik
Levofloxacin can be taken if allergic to Penicillin

People suffering from bacterial infections can take Levofloxacin if they are allergic to Penicillin.

According to NCBI, Levofloxacin achieved decent efficacy and safety as a first-line antimicrobial medication in people with Penicillin allergy.

Moreover, Levofloxacin is now recommended by the Infectious Diseases Society of America (IDSA).

It can treat acute bacterial Rhinosinusitis in children and adults with a history of type I hypersensitivity to Penicillin.

Although these drugs have many clinical benefits, you should always consult your doctor before administering them.

Fact:
To treat the allergic symptoms of Penicillin, a doctor can give you anti-histamins to block the activated responses by the immune system, along with, Corticosteroids to treat inflammation.

Conclusion

Levofloxacin and Penicillin are widely accepted antibiotics to treat various infections caused by bacteria.

However, Levofloxacin is not a Penicillin.

Levofloxacin belongs to the Fluoroquinolone class of antibiotics, whereas the penicillin family is in the beta-lactam antibiotic class of drugs.

Further, Levofloxacin can be used to treat CAP, chronic Prostatitis, and UTIs. 

Whereas, Penicillin can effectively treat Pneumonia, Diphtheria, and Meningitis.

Since Levofloxacin does not contain Penicillin, people allergic to Penicillin can administer Levofloxacin to treat bacterial infection.

Moreover, many researchers have approved the efficacy and safety of Levofloxacin for people sensitive to Penicillin.

Even though the use of Levofloxacin is suitable, you should consult your doctor to avoid any serious health complications.

Frequently Asked Questions

Is Levofloxacin a Penicillin group?

No, Levofloxacin is not included in the Penicillin class of antibiotics. Levofloxacin belongs to a third-generation Fluoroquinolone antibiotic and is effective in the treatment of bacterial infections. Levofloxacin can treat medical conditions such as Community-Acquired Pneumonia (CAP), Urinary Tract Infections, and Anthrax. You can consult your doctor before administering it.

Is Levofloxacin safe for Penicillin allergy?

Yes, Levofloxacin is safe and effective for people allergic to Penicillin. According to NCBI, the Levofloxacin antibiotic achieved decent efficacy and safety as a first-line medication with antimicrobial action in people with Penicillin allergy. However, it is recommended to consult your doctor and seek medically prescribed medication.

Are Levofloxacin antibiotics not Penicillin?

Levofloxacin antibiotics do not belong to the antibiotic class of Penicillin. Levofloxacin is a third-generation Fluoroquinolone antibiotic used to treat bacterial infections. Unlike Penicilline, these antibiotics are safe and effective with low risks of drug resistance. Therefore, people with Penicillin allergy can administer them after a doctor’s prescription.

How is Levofloxacin different from Penicillin-containing antibiotics?

Levofloxacin is an antibiotic belonging to the class of Fluoroquinolone, whereas Penicillin is in the beta-lactam antibiotic class of drugs. Also, Levofloxacin inhibits the synthesis of bacterial DNA, whereas, Penicillin inhibits an enzyme. Moreover, Penicillin-resistant bacteria is a growing concern, but there are less cases of Levofloxacin resistance.

Is Levofloxacin OK if allergic to Penicillin?

Yes, people allergic to Penicillin can take prescribed Levofloxacin. They belong to a separate class of antibiotics and have different modes of action. Moreover, according to NCBI, Levofloxacin is a recommended antibiotic by IDSA to treat acute bacterial Rhinosinusitis in children and adults allergic to Penicillin.

Citations:
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