How Long Does It Take for Levofloxacin to Work?

Dinesh Patel
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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how long does it take for levofloxacin to work

Levofloxacin, known by its brand name Levaquin, is a potent Fluoroquinolone antibacterial medication frequently prescribed to treat various bacterial infections. 

This includes Pneumonia, Sinusitis, skin infections, Urinary Tract Infections, Prostatitis, Anthrax, and even Plague.

Its versatility in addressing these conditions has made it a valuable tool in the fight against bacterial pathogens. 

In this article, we will explore how long does it take for Levofloxacin to work and discuss factors that may influence its effectiveness.

Levofloxacin’s rapid absorption

One of the key advantages of Levofloxacin is its rapid absorption in the body. 

It is quickly absorbed into the bloodstream when taken orally, achieving peak concentrations within a few hours. 

This swift absorption allows the medication to start combating the infection promptly.

Dosage and duration of treatment

The dosage of Levofloxacin can vary depending on the type of infection and the patient’s age. 

A study has shown that the dosing regimen of Levofloxacin plays a crucial role in its effectiveness. 

A high-dose (750 mg) short-course (5 days) of once a day Levofloxacin is approved for use in the United States to treat various infections. 

However, the treatment duration may differ based on the severity and nature of the infection.


Pneumonia is a common causeSource: 89Stocker

For adults with hospital-acquired Pneumonia, a typical regimen consists of 750 mg taken once every 24 hours for 7 to 14 days. 

In cases of community-acquired Pneumonia, the recommended dosage is 500 mg daily for 7 to 14 days and 750 mg, taken once every 24 hours for 5 days.


The duration and dosage for acute bacterial Sinusitis depends on the bacteria causing the infection. 

Typically, it ranges from 500 mg once daily for 10-14 days to 750 mg once daily for 5 days.

Sinusitis affects approximately 31 million people each year in the United States alone. It can cause various symptoms, including nasal congestion, facial pain, and headaches.

Skin infections

Levofloxacin can be prescribed for complicated or uncomplicated skin and skin structure infections. 

Dosages typically range from 500 mg (uncomplicated infection) to 750 mg (complicated infection) once a day for 7 to 14 days.

Urinary Tract Infections

For uncomplicated UTIs, the recommended dosage is 250 mg, taken once daily for 3 days. 

A common regimen for complicated UTI or acute Pyelonephritis is 250 mg for 10 days and 750 mg, taken once a day for 5 days.

Chronic conditions

To treat Chronic Bacterial Prostatitis due to E coli or E faecalis Levofloxacin has been proven to be effective. 

In such chronic cases , the dosage is 500 mg, taken once daily for 28 days.

Special cases

Levofloxacin is also used for specific situations, such as post-exposure Prophylaxis for Inhalational Anthrax, where adults might take 500 mg daily for 60 days.

Levofloxacin may cause serious side effects, including tendon rupture and nerve damage. If you experience sudden pain, swelling, or inflammation in your joints or tingling/numbness, stop taking the medication and contact your doctor immediately.

How long does it take to see results of Levofloxacin

After taking a dose of Levofloxacin, the highest concentration of the medication in your bloodstream typically occurs within one to two hours.

However, it may take up to three days before you notice significant improvements in your symptoms.

The effectiveness of Levofloxacin can vary depending on several factors.

  • Severity of infection: In more severe cases, it may take a little longer for Levofloxacin to produce noticeable improvements. However, its rapid absorption ensures that it begins fighting the infection soon after ingestion
  • Individual factors: Patient’s overall health, immune system function, and the presence of any underlying medical conditions can influence how quickly they respond to Levofloxacin
  • Type of infection: The specific type of infection being treated can impact response time. Some infections may respond more quickly to Levofloxacin than others

It’s important to complete the course of Levofloxacin as your doctor prescribes, even if you start feeling better before the medication is finished. 

This is crucial to ensure that the infection is fully treated and prevent antibiotic resistance.

Important considerations

Adequate water intake is essential for maintaining a healthy urinary tractSource: Евгений Харитонов_from_Getty_Images
Adequate water intake

While Levofloxacin treats infections readily, there are some steps you can take to ensure its effectiveness and prevent potential complications.  

  • Always take Levofloxacin as directed by your healthcare provider
  • The tablet form can be taken with or without food, while the liquid should be taken 1 hour before or 2 hours after eating
  • Ensure you are hydrated by drinking 8 ounces of water to prevent the crystal formation in urine
  • Try to take Levofloxacin at the same time each day to maintain consistent levels of the drug in your body
  • If your symptoms worsen or do not improve during treatment, contact your doctor promptly
  • Do not stop taking Levofloxacin without consulting your healthcare provider unless you experience serious side effects
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Levofloxacin, a potent antibiotic, is an essential tool in the battle against various bacterial infections, ranging from Pneumonia and Sinusitis to UTI and even Anthrax. 

The effectiveness of Levofloxacin, however, can depend on factors such as the severity of the infection, individual health, and the type of infection being treated. 

However, it takes upto three days for you to notice any improvements in symptoms. 

Additionally, it is crucial to adhere to the prescribed dosage and complete the full course of treatment to ensure that the infection is thoroughly eradicated.

Important considerations include maintaining consistent dosing schedules and seeking medical advice if symptoms worsen or persist during treatment. 

These steps are essential to maximize the effectiveness of Levofloxacin and minimize the risk of complications.

Frequently Asked Questions

How quickly does Levofloxacin start working?

Levofloxacin is rapidly absorbed into the bloodstream and typically starts to work within the first few days of treatment. However, it may take up to three days to notice significant symptom improvements.

Can Levofloxacin be used in children and older adults?

Levofloxacin use in children younger than 17 is not  generally recommended for certain conditions. For older adults, especially those over 65, dosage adjustments may be necessary due to changes in kidney function. Consult your healthcare provider for guidance in these cases.

Is Levofloxacin 500mg a strong antibiotic?

Yes, Levofloxacin 500mg is considered a strong antibiotic. Levofloxacin is a potent Fluoroquinolone antibiotic used to treat many bacterial infections. Its effectiveness is attributed to its ability to target and kill various types of bacteria effectively.

Is 5 days of Levofloxacin enough?

The duration of Levofloxacin treatment depends on the type and severity of the infection being treated. Sometimes, a 5-day course of Levofloxacin may be sufficient to treat the infection effectively. However, for other conditions, a longer period of treatment, typically 7 to 14 days, may be necessary.

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