Normal Estradiol Levels by Age: Understanding Hormonal Balance

Dinesh Patel
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

Last Updated:

normal estradiol levels by age

Estradiol, a form of Estrogen, plays a crucial role in various physiological processes in both males and females. 

It is especially important in reproductive health. This hormone also influences bone metabolism, cardiovascular health, and overall well-being. 

Understanding normal Estradiol levels by age is essential for assessing hormonal balance and identifying potential health issues related to Estrogen levels. 

In this article, we will explore the reference ranges of Estradiol at different stages of life and delve into the factors influencing Estradiol levels.

Estradiol levels in males

In males, Estradiol levels remain relatively low throughout life compared to females. 

The reference range for Estradiol in males varies depending on Tanner stages, reflecting how boys develop throughout puberty. 

Fact:
Tanner age is a widely used classification system for assessing the progression of sexual development during puberty in children and adolescents. The Tanner staging system provides a standardized framework for evaluating the physical changes that occur during puberty, including the development of secondary sexual characteristics like breast development in females and genital development in males.

As puberty progresses, Estradiol levels gradually increase. 

By Tanner Stage V (adult stage), the normal Estradiol levels by age in males is typically 10-40 pg/mL.

Normal Estradiol levels by age in males

The following table tells the normal Estradiol levels in different stages of development in males:

Tanner StageMean AgeRange
Stage I7.1Undetectable-13 pg/mL
Stage II12.1Undetectable-16 pg/mL
Stage III13.6Undetectable-26 pg/mL
StageIV15.1Undetectable-38 pg/mL
Stage V1810-40 pg/mL

Estradiol levels in females

In females, Estradiol levels fluctuate throughout the menstrual cycle, reflecting the dynamic changes that occur during reproductive years. 

During Tanner Stage I (prepubertal stage), Estradiol levels are typically undetectable to 20 pg/mL. 

With the onset of puberty, Estradiol levels increase

By Tanner Stage V (adult stage), the normal range for Estradiol in females is 15-350 pg/mL. 

It is important to note that Estradiol levels vary widely during the menstrual cycle, reaching their peak during the preovulatory phase.

Normal Estradiol levels by age in females

To know about the normal levels of Estradiol in females during their growing years, read the following table:

Tanner StageMean AgeRange
Stage I7.1Undetectable-20 pg/mL
Stage II10.5Undetectable-24 pg/mL
Stage III11.6Undetectable-60 pg/mL
StageIV12.315-85 pg/mL
Stage V14.515-350 pg/mL

Normal Estradiol levels in postmenopausal women

After Menopause, when a woman’s menstrual cycles have ceased for at least 12 consecutive months, Estradiol levels decline significantly. 

In postmenopausal women, Estradiol levels are typically below 10 pg/mL, reflecting the reduced ovarian production of Estrogen. 

The decline in Estradiol is primarily due to the cessation of ovarian follicle development and the reduction in ovarian function.

Factors influencing Estradiol levels

Women suffering from PCOS painSource: A's_Image
Abdominal pain (PCOS symptom)

Several factors can influence Estradiol levels, including age, Body Mass Index (BMI), underlying medical conditions, medications, and reproductive status. 

  • Age plays a significant role, as Estradiol levels naturally decline with advancing age, particularly in postmenopausal women
  • BMI can also impact Estradiol levels. Adipose tissue has an enzyme called Aromatase, which converts Androgens into Estradiol or Estrogen. Therefore, individuals with higher levels of body fat may have higher Estradiol levels
  • Medical conditions like Polycystic Ovarian Syndrome (PCOS) can lead to elevated Estradiol levels in females
  • Conversely, conditions affecting the ovaries or adrenal glands may decrease Estradiol production 
  • Medications, including hormonal therapies and certain drugs used to treat breast cancer, can also affect Estradiol levels

Importance of Estradiol management

Monitoring Estradiol levels is crucial for various clinical applications. 

In females, Estradiol measurement assists in evaluating reproductive function, assessing infertility, and diagnosing conditions such as PCOS or Estrogen-producing tumors.

It is imperative during assisted reproduction protocols, such as in vitro fertilization, where precise monitoring of Estradiol levels helps determine the optimal time for ovulation induction.

For women undergoing Hormone Replacement Therapy (HRT), maintaining Estradiol levels within the reference range for premenopausal women is a key objective.

Warning:
Hormone Replacement Therapy (HRT) has potential risks and considerations. Long-term use may increase the risk of cardiovascular diseases and certain cancers. HRT should be individualized, considering age, health, and risk factors. 

Healthcare providers can adjust HRT doses by monitoring Estradiol levels and ensuring the desired therapeutic effects.

In postmenopausal women, Estradiol levels are generally kept below the lower limit of the premenopausal reference range. 

This approach reduces the risk of hormone-related cancers and other complications associated with prolonged Estrogen exposure.

Recommended Article:
Estradiol is often referred to as Estrogen. However, there is a difference between the two.
To know how they differ from each other, read, Estradiol vs Estrogen: Understanding the Differences and Similarities.

Conclusion

Understanding the normal Estradiol levels by age at different stages of life is crucial for assessing hormonal balance and identifying potential health issues related to Estrogen.

Males have low Estradiol levels than females. Normal Estradiol levels in an adult male are 10-40 pg/ML. 

An adult female’s Estradiol level is typically between 15-350 pg/ML. During Menopause, Estradiol level declines significantly and is below 10 pd/ML.

Proper monitoring of Estradiol levels helps healthcare providers make informed decisions regarding diagnosis, treatment, and management of various conditions.

It’s important to note that Estradiol levels can be influenced by various factors such as age, BMI, underlying medical conditions, medications, and reproductive status.

By understanding the normal Estradiol levels by age, individuals and healthcare providers can work together to promote hormonal balance and optimize overall health and well-being.

Frequently Asked Questions

What is the Estradiol level for the period?

During the early to mid follicular phase of the menstrual cycle, which occurs in the days following the end of menstruation, Estradiol levels typically range from 20 to 80 pg/mL. Estradiol levels can peak at approximately 200 to 500 pg/mL during the preovulatory LH surge. 

What is a high Estradiol level?

A high Estradiol level typically refers to an elevated concentration of Estradiol in the blood. While the threshold for what is considered high may vary depending on the context and the normal reference range, it generally indicates an excess of Estrogen.

What are the dangers of high Estradiol? 

In fertility treatment, excessively high Estradiol levels may indicate Ovarian Hyperstimulation Syndrome (OHSS), characterized by enlarged ovaries, fluid accumulation in the abdomen, and potentially severe complications. OHSS can be associated with abdominal pain, nausea, bloating, and shortness of breath.

What is the ideal Estradiol level for pregnancy?

Estradiol levels can increase gradually during the early stages, such as the first trimester. However, there is no defined ideal Estradiol level for pregnancy, as it can depend on factors like maternal health and underlying conditions. Reference ranges for Estradiol levels may vary slightly among different laboratories and healthcare systems. 

Citations:
WowRxPharmacy uses only high-quality sources while writing our articles. Please read our content information policy to know more about how we keep our content reliable and trustworthy.

More Articles Like This

Leave a Comment

Receive the latest articles in your inbox!