Estrogen Cream For Vaginal Dryness: Restoring Relief

Amisha Jain
Medically reviewed by
Dr. Kaushal

Review medical content on WOW Rx Pharmacy, so that accurate drug use information is easily accessible to everybody.
Dr. Akansha is a licensed Clinical Pharmacologist. She possesses remarkable knowledge in Pharmacovigilance, prescription analysis, drug information, and drug safety services. Additionally, she is a keen learner and an educator.

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estrogen cream for vaginal dryness

Estrogen creams are emerging as a potential game-changer in providing relief from vaginal dryness.

Statistics estimate 50% of postmenopausal women experience vaginal dryness.

This issue can also affect women during their reproductive years due to hormonal fluctuations. 

These creams are given to restore hormonal balance and help reduce discomfort.

Keep reading to learn in detail about Estrogen cream for vaginal dryness.

Working of Estrogen vaginal cream

Estrogen creams typically contain Estradiol or Estrone, which are forms of the hormone Estrogen.

Conjugated Estrogens vaginal cream is another option to treat vaginal dryness and other symptoms associated with the menopausal phase.

Conjugated Estrogens are medications containing a combination of Estrogens to be used as hormone therapy to treat Menopausal symptoms.

Estrogens used vaginally are low doses for treating local problems of the urinary tract and the genitals, such as dryness, soreness, itching, and redness of the vagina or the vulva.

When applied vaginally, it is absorbed into the bloodstream and makes up for the reduced Estrogen levels, which causes vaginal dryness. 

They have almost the same effect as oral Estrogen pills, except that they do not stop hot flashes or protect against Osteoporosis.

How to use vaginal cream

Before you start using Estrogen vaginal cream, it is crucial to address that these creams are to be used vaginally only. 

It is also necessary to consult a healthcare provider before you start the treatment.

They will assess your symptoms, medical history, and individual needs to determine if Estrogen cream is an appropriate treatment option for you.

If prescribed, you can follow the below steps to apply the cream:

  • Wash your hands thoroughly with soap and water
  • Find a comfortable and relaxed position that allows easy access to your vaginal area
  • If your Estrogen cream comes with an applicator, load the applicator with the prescribed amount of cream. Squeeze the tube gently until the applicator is filled with the correct dosage of cream
  • Ensure to replace the cap on the cream tube after loading the applicator
  • Gently put the applicator into the vagina as far as it comfortably goes without causing any discomfort
  • Slowly and gently press the plunger on the applicator to release the cream into the vaginal canal
  • Once the cream is dispensed, carefully remove the applicator from the vagina
  • Dispose of the applicator as per the instructions provided with the product. Do not flush the applicator down the toilet
  • If the applicator is reusable, clean it thoroughly with mild soap and warm water after each use
  • After the application is complete, wash your hands again with soap and water to ensure cleanliness and hygiene
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Various dosage of estrogen creamSource: Dmitriy Sidor from Getty Images
Various dosage

The dosage and duration of using Estrogen creams will vary from individual to individual.

It will also depend on the strength of the medication and the way one reacts to the treatment.

The number of doses per day, the duration between each dose, and the length of the treatment might vary based on the medical problem being treated.

It is recommended to follow your doctor’s prescription to avoid inappropriate dosing.

Side effects of Estrogen cream for vaginal dryness

The risk of any severe side effects while using low doses of vaginal Estrogen cream is highly unlikely.

Most women observe no side effects or mild effects only and typically require no medical assistance.

These include:

  • Breast pain or tenderness
  • Bloating
  • Nausea and vomiting
  • Vaginal irritation

Some other side effects which should be reported include:

  • Allergic reaction
  • Blood clot
  • Changes in the breast tissue
  • Increased blood pressure
  • Unusual vaginal discharge, odor, or itching

Immediately visit a doctor if you observe any visual changes or fluid retention in the body.

Do not consume tobacco while using Estrogen cream. Doing so might increase the risk of blood clots or a stroke.

Potential interactions

Before using any medication, it is important to know if the medication is safe for you to use.

It is, therefore, crucial to reveal your entire medical history to your healthcare provider for proper assessment.

They might not prescribe Estrogen cream for vaginal dryness in case you have:

  • Allergy to any of the components of the cream
  • Health problems such as bleeding disorder, risk of blood clotting, or any deficiencies
  • Liver or heart problems
  • Unexplained vaginal bleeding

It is also crucial to disclose all the medications and herbal supplements you are taking to avoid any possible interactions.

Some such medications include Anastrazole, Carfilzomib, Exemestane, Fezolinetant, etc.

These medications might interact with Estrogen cream and impact the efficacy of either medication.

In addition to this, let your doctor know if you are pregnant, planning a pregnancy, or nursing a baby since this medication might not be suitable for you.


Always consult a DoctorSource: studioroman
Always consult a Doctor

There are certain things that you need to be cautious of while using Estrogen cream for vaginal dryness.

These include the following:

  • Check with your healthcare provider regularly to ensure that the medication is not causing any unwanted effects
  • Have a regular pelvic exam
  • Avoid using latex condoms, cervical caps, or diaphragm for up to 72 hours after applying the cream
  • Use the medication at bedtime for better absorption and improved effectiveness
  • Vaginal creams have a tendency to melt and leak out of the vagina. Use a panty liner or sanitary napkin to protect your clothing and avoid discomfort
  • Although low, there are changes that using Estrogen may increase your risk of ovarian or uterine cancer
  • Do not have sexual intercourse right after using the medication to avoid exposing your partner to the medication


Vaginal dryness can have a profound impact on a woman’s physical comfort, emotional well-being, and sexual satisfaction. 

Estrogen cream offers a promising solution for addressing vaginal dryness by restoring Estrogen balance in the bloodstream, thus alleviating symptoms. 

As with any medical treatment, consulting a healthcare expert is essential to determine the most suitable approach for your individual needs.

It will also help avoid the interaction of the medication with other drugs or diseases.

Adverse effects like breast pain or tenderness, bloating, nausea, and vomiting are commonly observed in individuals using Estrogen creams vaginally and resolve over time.

However, seek immediate medical attention in case you experience side effects such as an allergic reaction, blood clot, or changes in the breast tissue.

Consulting a healthcare provider before beginning this treatment is crucial, as they can offer personalized guidance and recommendations based on individual health considerations.

Frequently Asked Questions

How long does it take for Estrogen cream to help with dryness?

The time it takes for Estrogen cream to alleviate dryness varies among individuals. Some women may experience relief within a few days to a week, while for others, it might take a bit longer. Consistent use as directed by a healthcare provider is essential for optimal results.

Who should not use Estrogen cream?

Women with a history of certain health conditions, such as breast cancer, active blood clotting disorders, liver disease, and unexplained vaginal bleeding, should avoid using Estrogen cream. Consulting a healthcare provider before use is crucial for determining individual suitability.

Where is the best place to put Estrogen cream?

The best place to apply Estrogen cream is directly into the vaginal canal. It’s recommended to use an applicator to ensure accurate placement. Always follow the instructions from your doctor or the product’s packaging for proper application.

What is the best cream for Vaginal dryness?

The best cream for vaginal dryness varies based on individual preferences and needs. Some well-known options include Estradiol, Estrone, or Conjugated Estrogens cream. Consult a healthcare expert to help determine the most suitable option for your situation.

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