Comparing Progesterone Champions: Endometrin vs Prometrium
People often compare the two medications, Endometrin and Prometrium, which are powerhouses of Progesterone.
You may also search for the comparison because their active salt is the same, but their dosage regimens differ greatly. It’s also possible that you may have tried one of these medications but now want to try another one and see if it’s more effective.
Whatever your questions may be, they will all be answered in this article. Continue reading to know more about Endometrin vs Prometrium.
A Comparison: Prometrium vs Endometrin
| Aspect | Endometrin | Prometrium |
|---|---|---|
| Route of administration | Vaginal | Oral |
| Formulation | Vaginal insert (tablet-shaped suppository) | Oral capsules |
| Usage | Increase Progesterone in women with fertility issues | Secondary Amenorrhea, Prevention of Endometrial Hyperplasia |
| Dosage | 100 mg vaginal insert | Various dosages available |
| Frequency of administration | 2-3 times a day | Determined by prescribing healthcare provider |
| Type of Progesterone | Micronized | Micronized |
| FDA-approval | Approved | Approved |
| Side effects | Bloating, headache, nausea, blurred vision, difficulty breathing, constipation, changes in sexual desire, etc. | Bloating, headache, nausea, blurred vision, difficulty breathing, breast lumps, dark patches on the skin or face, etc. |
Formulation and usage
The significant difference between Endometrin and Prometrium lies in their formulations and modes of administration, with Endometrin being formulated as a tablet-shaped suppository.
This medication is administered through the vagina. You may take the help of an applicator to insert this medication.
On the other hand, Prometrium is available in the form of a capsule. Both formulations offer unique advantages, and the choice between them depends on individual patient needs and healthcare provider recommendations.
Endometrin vs Prometrium usage
Although both Endometrin and Prometrium have Progesterone as an active ingredient, their usage may differ. Endometrin is usually prescribed to women who have fertility issues. These women undergo fertility treatments, which may decrease their Progesterone levels.
Thus, this medication can be recommended to increase the hormone level and support a healthy pregnancy. Prometrium capsules are mainly given to women to prevent the following conditions:
- Prevention of Endometrial Hyperplasia: In this condition, your uterine lining becomes thick because of excess Estrogen and low Progesterone
- Secondary Amenorrhea: It is a condition in which you are given this medication if you had your periods in the past but now have gone through six or more months without menses
Progesterone medications are commonly used to alleviate symptoms of Premenstrual Syndrome (PMS) and Menopause.
Susten 100mg might also be considered an alternative to Endometrin and Prometrium, offering similar effectiveness at a more affordable price.
Dosage and frequency
Prometrium and Endometrin also differ in dosage and frequency. As per your condition, the doctor recommends the dosage factors of these medications, including the frequency of dosing and the intervals between each dose.
Usually, Endometrin is administered in the dosage of 100 mg. It can be inserted in the vagina two or three times a day. In the case of Prometrium, various dosages are available. The dosage and frequency of this drug depend upon the condition for which you are treated.
- To prevent Endometrial Hyperplasia: 200 mg per day, taken as a single dose at bedtime
- For treatment of Secondary Amenorrhea: 400 mg per day, taken as a single dose at night
FDA-approval
Endometrin and Prometrium have received approval from the US Food and Drug Administration (FDA). Endometrin, a Progesterone vaginal insert, was initially approved by the FDA in 1974.
In comparison, Prometrium, a Progesterone capsule, received FDA approval in 1998, several years after Endometrin.
Type of Progesterone
Different types of Progesterone can be administered to females, such as:
- Synthetic versions of the hormone Progesterone, such as Dydrogesterone, Medroxyprogesterone, Norethisterone, Levonorgestrel
- Micronized or natural Progesterone which is chemically identical to the human hormone
Endometrin and Prometrium are both forms of micronized Progesterone, which is favored for its enhanced absorption and consistent effects over other Progesterone formulations.
Endometrin vs Prometrium side effects
If you are confused about taking Endometrin or Prometrium based on side effects, let us clarify it. Following are some similar side effects of both these medications:
- Dizziness
- Changed or unusual vaginal discharge
- Bloating
- Headache
- Nausea
- Blurred vision
- Difficulty breathing
- Mood swings
- Chest pain
- Breast tenderness
- Rash
Endometrin may cause other side effects, such as:
- Vaginal pain or discomfort
- Constipation
- Changes in sexual desire
Prometrium may cause the following side effects:
- Frequent/ burning/ painful urination
- Breast lumps
- Dark patches on the skin or face
Takeaway
When we compare Endometrin vs Prometrium, it is evident that they have some similarities, such as containing micronized Progesterone. However, they differ in terms of formulation, route of administration, usage, dosage, and frequency.
Endometrin, available as a vaginal insert, is primarily used for fertility issues and inserted into the vagina twice or thrice daily. It is prescribed to women with fertility issues to support a healthy pregnancy.
On the other hand, Prometrium, an oral capsule, is commonly prescribed for conditions like preventing Endometrial Hyperplasia and Secondary Amenorrhea. The dosage and frequency of Prometrium depend on the specific condition being treated.
Both medications can cause similar side effects, such as nausea, bloating, chest pain, mood swings, and blurred vision. However, Endometrin may be considered a better option for fertility treatments compared to Prometrium due to its localized delivery and potentially lower risk of side effects.
Frequently Asked Questions
Is Endometrin a natural Progesterone?
Yes. Endometrin is a natural Progesterone approved by the US Food and Drug Administration. Micronized or natural Progesterone is chemically identical to the human hormone. It is mainly used for women with fertility issues.
What are the common side effects of Endometrin and Prometrium?
There are many common side effects of Endometrin and Prometrium. These include bloating, headache, nausea, blurred vision, difficulty breathing, mood swings, chest pain, breast tenderness, rash, etc.
Do you take Endometrin once or twice a day?
According to the US Food and Drug Administration, Endometrin is advised to be taken two or three times daily. It is available in a tablet-shaped suppository with a dose of 100 mg. You can insert it into your vagina with the help of an applicator.
What is the use of Endometrin and Prometrium?
Although Endometrin and Prometrium have the same active ingredient, Progesterone, they have different uses. Endometrin is given to women with fertility problems to have a healthy pregnancy. Prometrium is given in conditions like Secondary Amenorrhea and prevention of Endometrial Hyperplasia.
FDA-approval
Endometrin and Prometrium have received approval from the US Food and Drug Administration (FDA). Endometrin, a Progesterone vaginal insert, was initially approved by the FDA in 1974.
In comparison, Prometrium, a Progesterone capsule, received FDA approval in 1998, several years after Endometrin.
Type of Progesterone
Different types of Progesterone can be administered to females, such as:
- Synthetic versions of the hormone Progesterone, such as Dydrogesterone, Medroxyprogesterone, Norethisterone, Levonorgestrel
- Micronized or natural Progesterone which is chemically identical to the human hormone
Endometrin and Prometrium are both forms of micronized Progesterone, which is favored for its enhanced absorption and consistent effects over other Progesterone formulations.
Endometrin vs Prometrium side effects
If you are confused about taking Endometrin or Prometrium based on side effects, let us clarify it. Following are some similar side effects of both these medications:
- Dizziness
- Changed or unusual vaginal discharge
- Bloating
- Headache
- Nausea
- Blurred vision
- Difficulty breathing
- Mood swings
- Chest pain
- Breast tenderness
- Rash
Endometrin may cause other side effects, such as:
- Vaginal pain or discomfort
- Constipation
- Changes in sexual desire
Prometrium may cause the following side effects:
- Frequent/ burning/ painful urination
- Breast lumps
- Dark patches on the skin or face
Takeaway
When we compare Endometrin vs Prometrium, it is evident that they have some similarities, such as containing micronized Progesterone. However, they differ in terms of formulation, route of administration, usage, dosage, and frequency.
Endometrin, available as a vaginal insert, is primarily used for fertility issues and inserted into the vagina twice or thrice daily. It is prescribed to women with fertility issues to support a healthy pregnancy.
On the other hand, Prometrium, an oral capsule, is commonly prescribed for conditions like preventing Endometrial Hyperplasia and Secondary Amenorrhea. The dosage and frequency of Prometrium depend on the specific condition being treated.
Both medications can cause similar side effects, such as nausea, bloating, chest pain, mood swings, and blurred vision. However, Endometrin may be considered a better option for fertility treatments compared to Prometrium due to its localized delivery and potentially lower risk of side effects.
Frequently Asked Questions
Is Endometrin a natural Progesterone?
Yes. Endometrin is a natural Progesterone approved by the US Food and Drug Administration. Micronized or natural Progesterone is chemically identical to the human hormone. It is mainly used for women with fertility issues.
What are the common side effects of Endometrin and Prometrium?
There are many common side effects of Endometrin and Prometrium. These include bloating, headache, nausea, blurred vision, difficulty breathing, mood swings, chest pain, breast tenderness, rash, etc.
Do you take Endometrin once or twice a day?
According to the US Food and Drug Administration, Endometrin is advised to be taken two or three times daily. It is available in a tablet-shaped suppository with a dose of 100 mg. You can insert it into your vagina with the help of an applicator.
What is the use of Endometrin and Prometrium?
Although Endometrin and Prometrium have the same active ingredient, Progesterone, they have different uses. Endometrin is given to women with fertility problems to have a healthy pregnancy. Prometrium is given in conditions like Secondary Amenorrhea and prevention of Endometrial Hyperplasia.
