Are Fibroids Genetic: An Insight into Claims Behind Possible Mechanisms
Fibroids affect about 77 percent of women during their reproductive years.
Its exact cause remains a matter of debate, but many factors, such as obesity and hormones, can increase the risk of developing Fibroids.
Claims also suggest that one such factor is genes.
So, are Fibroids genetic, or is there substantial scientific evidence supporting this claim?
Read this article to find out if there is any scientific evidence about the genetic risk of Fibroids.
Are Uterine Fibroids genetic
It is true that genetics cause Fibroids.
However, they are not the primary cause or the only cause most of the time.
Genetics is a risk factor that increases the chances of developing Fibroids.
Mostly, the genes that the Fibroids contain are different from those in typical uterine muscles.
Evidence from a study by S A Treloar suggested that identical twins (monozygotic twins) are more likely to have Fibroids than dizygotic twins.
This consolidates the claims of genetic contribution in the case of Fibroids.
Moreover, another study by Ryo Maekawa found 120 genes with different DNA methylation and mRNA (messenger Ribonucleic Acid) expression between Fibroids and adjacent myometrium.
DNA methylation is the chemical modification of DNA retained when DNA divides for cell formation. It can alter the gene expression.
It also found 22 different target genes of Estrogen receptors.
These factors express the clinical mechanism by which Uterine Fibroids form.
Further explanation about the genetic factor of Fibroids was given in a review by Veronica Medikare.
It sums up that Uterine Fibroids have 40 to 50 percent genetic abnormalities.
Out of all, chromosomes 6,7,12, and 14 are responsible for most of the abnormalities related to Fibroids.
The dysregulation of genes such as HMGIC and HMGIY leads to the formation of these tumors.
RAD51L1 acts as the translocation partner of HMGIC, which helps disrupt the gene structure and Fibroid development.
Not only this, but other conditions like Endometriosis also share similar genetic factors.
This area needs more studies that can effectively solve numerous female health conditions simultaneously.
It presents a hope of finding an efficient solution in the future for preserving women’s health.
To know more about the connection and comparison between these two female health concerns, read Endometriosis and Fibroids.
Are Uterine Fibroids hereditary
Family history can be a contributing factor in developing Fibroids.
A study by E M Vikhlyaeva found that Fibroids genetic predisposition was 2.2 times higher in first-degree female relatives with a family history of two or more Fibroids cases.
Genetic predisposition means the likelihood of developing a disease based on family history or genetic variants. It does not mean the individual will always develop the disease.
So, if your sister or mother has Fibroids, you might have a higher chance of developing them.
Although, this may not always be the case.
Uterine Fibroids genetic test
In 2022, the National Institutes of Health provided funds to researchers who found prototype genetic tests helpful in detecting Fibroids.
It could detect the severity of Fibroids while also predicting the risk of developing them.
The researchers also found that not a single gene but rather variant gene combinations were responsible.
They created Polygenic Risk Scores (PRS) based on the data of the study, which can be a predictive element.
PRS can predict a woman’s risk of developing Fibroids.
This can make a great difference in not only finding the treatment for Fibroids but also preventing them.
Conclusion
Fibroids can be developed due to genetic changes or abnormalities.
Several studies have established a relationship between genes and Fibroids.
One of them explains that Uterine Fibroids have 40 to 50 percent genetic abnormalities, which lead to the development of Fibroids.
It also shares genetic similarities with other female health conditions like Endometriosis.
Moreover, it can also be hereditary sometimes, as women with a sister or mother having Fibroids have a higher chance of developing them.
However, this may not always be the case.
Currently, the Polygenic Risk Score is a predictive element that can analyze the risk of developing Fibroids.
It can become a big asset in the future for developing new modes of treatment and prevention of Fibroids.
Frequently Asked Questions
Can Fibroids be passed on genetically?
Yes, Fibroids can be passed on genetically. Studies have found that Fibroids have genetic abnormalities. Moreover, those with a sister or mother having Fibroids are more likely to develop Fibroids. However, it is not necessary for all such women to develop Fibroids.
Are Fibroids genetic or hereditary?
Fibroids can be both genetic and hereditary. Genetic abnormalities are present in Uterine Fibroids, which lead to the development of Fibroids. Moreover, women with first-degree relationships to those with Fibroids have a 2.2 times higher risk of developing Fibroids.
Who is prone to Fibroids?
The risk of Fibroids depends on many factors. Genes and a family history of Fibroids are also two prominent ones. Besides, other factors like obesity, ethnicity, age, high blood pressure, and vitamin D deficiency can also increase the risk of Fibroids.
Should I worry if I have Fibroids?
Many women do not even know they have Fibroids as they experience no symptoms. However, other women do experience symptoms like heavy periods or pain. So, if you do not experience symptoms, you will not need treatment. However, in case of discomfort, always seek medical attention.
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