{"id":21579,"date":"2023-11-02T09:02:40","date_gmt":"2023-11-02T13:02:40","guid":{"rendered":"https:\/\/wowrxpharmacy.com\/blog\/uncategorized\/brca1-vs-brca2\/"},"modified":"2024-11-25T01:51:20","modified_gmt":"2024-11-25T06:51:20","slug":"brca1-vs-brca2","status":"publish","type":"post","link":"https:\/\/wowrxpharmacy.com\/fr\/blog\/womens-health\/brca1-vs-brca2\/","title":{"rendered":"BRCA1 vs BRCA2: Understanding Genetic Cancer Risks"},"content":{"rendered":"

BRCA1 and BRCA2 are the genes linked to an increased risk of ovarian and breast cancer.

These genes usually help in preventing cancer by repairing damaged DNA.

But when mutated, these genes make a person more prone to various types of cancer<\/a>.

So, it is important to understand the difference between these two genes and assess the cancer risk.

According to National Cancer Institute, BRCA1 and BRCA2 mutation prevalence is about 0.2% to 0.3% in the general population.

In this article, we will discuss BRCA1 vs BRCA2<\/a> on the basis of the increased risk of cancer and mutation.<\/p>\n\n\n

A quick review: BRCA1 vs. BRCA2<\/h2>\n\n\n
<\/th>BRCA1 Mutation<\/strong><\/th>BRCA2 Mutation<\/strong><\/th><\/tr><\/thead>
Associated Cancers<\/strong><\/td>Breast, ovarian, fallopian tube, peritoneal<\/td>Breast, ovarian, pancreatic, prostate<\/td><\/tr>
Breast Cancer Risk<\/strong><\/td>Increased risk of triple-negative breast cancer<\/td>Increased risk of breast cancer<\/td><\/tr>
Ovarian Cancer Risk<\/strong><\/td>Increased risk of ovarian, fallopian tube, and peritoneal cancers<\/td>Increased risk of ovarian cancer<\/td><\/tr>
Other Cancer Risks<\/strong><\/td>No increased risk of pancreatic or prostate cancer<\/td>Increased risk of pancreatic and prostate cancers<\/td><\/tr>
Inheritance<\/strong><\/td>Autosomal dominant<\/td>Autosomal dominant<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n

What is BRCA1 and BRCA2<\/h2>\n\n\n

BRCA1 and BRCA2 are two Breast Cancer genes generally pronounced as BRACA.

These are short names given to<\/a> the terms BR<\/strong>east CA<\/strong>ncer susceptibility gene 1<\/strong> et BR<\/strong>east CA<\/strong>ncer susceptibility gene 2<\/strong>.

Both genes are present in everyone but can increase your chances of breast and ovarian cancer if mutated.

These genes are inherited either from your mother or your father.

However, not everyone who inherits BRCA1 or BRCA2 mutation will get cancer.

BRCA1 and BRCA2 are tumor suppressor genes because they help<\/a> repair DNA damage and maintain genomic stability.<\/p>\n\n\n

Difference between BRCA1 and BRCA2<\/h2>\n\n\n

BRCA1 and 2 are two completely different genes, even though mutation on either BRCA1 or BRCA2 cause cancer.

BRCA1 was first<\/a> discovered in 1990 on chromosome 17, and BRCA2 was found on chromosome 13.

The main difference is the type of cancer associated with the genes and their presence in specific populations.

BRCA1 mutation increases the risk of<\/a> Triple-Negative Breast Cancer and has a higher risk of Ovarian Cancer.

On the other hand, BRCA2 is commonly associated with breast, ovarian, pancreatic, and prostate cancer.

The prevalence of BRCA1 mutation is higher<\/a> in the Ashkenazi and the Jewish population.

While BRCA2 mutations are prevalent in Iceland, Netherlands, and Norway individuals.<\/p>\n\n\n

Associated cancer risks<\/h2>\n\n\n

As per a study<\/a> published by the National Center of Biotechnology Information explains the risk of hereditary Breast and Ovarian Cancer due to BRCA1 and BRCA2 mutations.<\/p>\n\n\n\n

The risk of cancer in individuals with mutations compared to the general population is as follows:<\/p>\n\n\n\n

<\/td>General Population Risk<\/strong><\/td>Increased risk<\/strong><\/td><\/tr>
BRCA1<\/strong><\/td>BRCA2<\/strong><\/td><\/tr>
Cancer du sein<\/strong><\/td>12%<\/td>55%-72% by the age of 70 years<\/td>45%-69%<\/td><\/tr>
Ovarian Cancer<\/strong><\/td>1%-2%<\/td>39%-44%<\/td>11%-17%<\/td><\/tr>
Male Breast Cancer<\/strong><\/td>0.1%<\/td>1%-2%<\/td>6%-8%<\/td><\/tr>
Prostate Cancer<\/strong><\/td>6% by the age of 69 years<\/td>21% by the age of 75 years29% by the age of 85 years<\/td>27% by the age of 75 years60% by the age of 85 years<\/td><\/tr>
Pancreatic Cancer<\/strong><\/td>0.5%<\/td>1%-3%<\/td>3%-5% by the age of 70 years<\/td><\/tr>
Melanoma (cutaneous & ocular)<\/strong><\/td>1.6%<\/td><\/td>Higher risk<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n
Fait:<\/div>
BRCA1 and BRCA2 mutation doesn\u00e2\u0080\u0099t mean you will surely get cancer; it just increases your chances of getting various types of cancer. <\/div><\/div>\n\n\n

Comparing the risk<\/h2>\n\n\n
\"Consult
Consult a Gynecologist <\/figcaption><\/figure>\n\n\n\n

The BRCA1 and BRCA2 gene mutations increase the risk of developing certain cancers, including breast and ovarian cancer.

However, as stated above, BRCA1 is associated with higher risks<\/a> of Triple-Negative Breast Cancer, a more aggressive cancer.

Triple-Negative Breast Cancer is hard to treat than other types of Breast Cancer.

By the age of 70, women with BRCA1 mutations have a higher chance of getting Breast Cancer than BRCA2.

Cancer.net<\/a> states that individuals with BRCA2 mutation have a 7% risk of developing Male Breast Cancer. 

Whereas mutation in the BRCA1 gene has a 1% risk of developing Male Breast Cancer<\/a>.

Both genes, when mutated, peut causer<\/a> severe health problems such as ovarian, prostate, uterine, cervical cancer, and melanoma.<\/p>\n\n\n

Avertissement:<\/div>
Consult your doctor if you have any abnormal lump near your breast. This can be a symptom of various health conditions or cancer. <\/div><\/div>\n\n\n

BRCA1 and BRCA2 genetic testing<\/h2>\n\n\n
\"Saliva
Saliva test<\/figcaption><\/figure>\n\n\n\n

The BRCA genetic test uses a sample of your saliva, blood, or saliva from inside your cheeks.

These test checks for any changes in your BRCA1 and BRCA2 genes.

Changes in your genes are known as mutated genes or gene variants, and not all are harmful.

Certains des gene tests<\/a> are as follows:<\/p>\n\n\n\n