{"id":25574,"date":"2024-03-18T10:40:11","date_gmt":"2024-03-18T14:40:11","guid":{"rendered":"https:\/\/wowrxpharmacy.com\/blog\/uncategorized\/what-causes-fibroids\/"},"modified":"2024-07-31T04:05:42","modified_gmt":"2024-07-31T08:05:42","slug":"what-causes-fibroids","status":"publish","type":"post","link":"https:\/\/wowrxpharmacy.com\/es_co\/blog\/salud-femenina\/what-causes-fibroids\/","title":{"rendered":"What Causes Fibroids: Risks and Contributing Factors"},"content":{"rendered":"

Uterine fibroids are non-cancerous tumors in the walls of the uterus that affect women in their reproductive years.

Approximately 25% of women have fibroids, and this is apparent in up to 70% of women in Menopause.

Fibroids can cause various clinical manifestations and lead to severe complications, including infertility. 

But have you wondered what causes fibroids? And what are the risk factors that elevate the risk of developing it?

The major causes of fibroids include hormonal and gene changes. Aging and family history are also significant risk factors for developing it.

Understanding these underlying causes and risk factors is crucial in preventing the development of fibroids and seeking treatment if required.

This comprehensive article elaborates on such causes of fibroids and be cautious to prevent them.<\/p>\n\n\n

Causes of fibroids<\/h2>\n\n\n

According to the National Institute of Child Health and Human Development, the exact<\/a> cause of uterine fibroids is unknown.

However, numerous underlying factors can help in the growth of the fibroids.

Some of the most common causes of uterine fibroids in women are as follows:<\/p>\n\n\n

Hormones<\/h3>\n\n\n

Of all the underlying causes of fibroids, Estrogen and Progesterone<\/a> are critically considered the main reasons.

Fibroids are considered<\/a> Estrogen-dependent as no prepubertal cases have been reported, and tumors tend to shrink naturally after Menopause<\/a>.

In addition, a 2010 study on rats showed<\/a> that Progesterone is essential for the growth and maintenance of uterine fibroids.<\/p>\n\n\n

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Gene changes<\/h3>\n\n\n

Some uterine fibroids are developed as a result of genetic mutations.

As per a study in 2019, the main genetic drivers<\/a> for causing fibroids are MED12, HMGA2, FH, and COLA45-COL4A6 genes.<\/p>\n\n\n\n

Also Read: <\/strong>To learn more about the role of genetics in developing fibroids, read \u201cAre Fibroids Genetic: An Insight into Claims Behind Possible Mechanisms.<\/a>\u201d<\/p>\n\n\n

Insulin-like growth factor<\/h3>\n\n\n
\"insulin\"
Insulin written on a paper<\/figcaption><\/figure>\n\n\n\n

Insulin-like growth factor is also an important factor in the development of fibroids.

Both myometrium and fibroid tissue contain<\/a> large amounts of Insulin-like growth factors compared to other protein growth factors.

The effect of Insulin-like growth factor, in the absence<\/a> of sex steroid hormones, has a direct role in the development of fibroids.<\/p>\n\n\n

Extracellular matrix (ECM)<\/h3>\n\n\n

ECM increases the fibroids and makes<\/a> them fibrous.

Further, ECM can also store growth factors and induce biological changes within the cell.<\/p>\n\n\n

Risk factors for fibroids<\/h2>\n\n\n

Numerous risk factors can play a role in the development of uterine fibroids in women.

Some of the risk factors of fibroids are as follows:<\/p>\n\n\n

Age<\/h3>\n\n\n

Growing age is a significant risk factor for fibroid development<\/a>, especially in premenopausal women who are older than 40 years.<\/p>\n\n\n\n

The table below shows how age plays a significant role in causing fibroids:<\/p>\n\n\n\n

Ages<\/strong><\/th>Percentages of women having uterine fibroids<\/strong><\/th><\/tr><\/thead>
35-49 years African American women<\/strong><\/td>60%<\/td><\/tr>
Above 50 years African American women<\/strong><\/td>80%<\/td><\/tr>
Less than 35 years of white women<\/strong><\/td>50%<\/td><\/tr>
Above 50 years of white women<\/strong><\/td>70%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n

Family history<\/h3>\n\n\n

A family history<\/a> of uterine fibroids can cause them in women.

Women who have a close relative with fibroids should seek a prompt medical diagnosis for the early detection of fibroids.<\/p>\n\n\n

Demographic factors<\/h3>\n\n\n

Demographic factors, such as race, are also associated with the high-risk factors of developing fibroids.

For example, African women are more likely<\/a> to develop fibroids compared to caucasian or white women at a younger age.

African women have three times, and Hispanic women have two times more chances of developing<\/a> uterine fibroids when compared with white women.

Furthermore, African women may have fewer chances of fibroids shrinking in their perimenopausal years.<\/p>\n\n\n\n

<\/div>\n\n\n\n\n\n
\"<\/figure>\n\n\n\n\n

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Early menarche<\/h3>\n\n\n

Many older studies have reported that women who tend to experience early menarche are certainly at higher risk of developing fibroids.

It happens because women who tend to have early menarche or late Menopause, on average<\/a>, have increased exposure to the ovulatory cycles.

A longer lifetime exposure to the ovulatory cycle can increase fibroids risk.<\/p>\n\n\n

Low Vitamin D<\/h3>\n\n\n

Vitamin D deficiency is an important factor associated with the risk of developing fibroids.

Further, Vitamin D deficiency is ten times more com\u00fan<\/a> among African American women when compared to other women.<\/p>\n\n\n

Diet<\/h3>\n\n\n

Women who eat less plant-based diets, such as vegetables and fruits, can eventually<\/a> grow fibroids at some stage.

Further, women who consume excessive amounts of red and fatty meat are also at risk.

There are some studies that support<\/a> that drinking soybean milk can also elevate the chances of developing uterine fibroids.<\/p>\n\n\n\n

Also Read: <\/strong>Want to know how to shrink fibroids with dietary changes, read \u201c7 Foods for Shrinking Fibroids Effectively.<\/a>\u201d<\/p>\n\n\n

Excessive alcohol intake<\/h3>\n\n\n

Lifestyle factors, such as excessive alcohol consumption, can also elevate<\/a> the risk of developing fibroids in the following ways:<\/p>\n\n\n\n