Comparing Anastrozole vs Clomid: Which is the Best Anti-Estrogen?
Are you curious about the differences between Anastrozole and Clomid?
These medications have distinct purposes and applications.
Anastrozole is primarily used for breast cancer treatment and works by reducing Estrogen levels.
On the other hand, Clomid is a fertility medication that stimulates ovulation in women.
Understanding the contrasts between Anastrozole and Clomid is crucial when considering their usage.
Continue reading to know more about the key differences between the two and which is more suitable for treating your condition.
Quick reviews
There are several clinical studies on Anastrozole vs Clomid.
One study indicated that hypoandrogenic subfertile males could benefit from a treatment plan that combines the fertility drugs Clomiphene citrate (Clomid) and Anastrozole.
Another study published in the New England Journal of Medicine (NEJM) compared Letrozole and Clomiphene for infertility in Polycystic Ovary Syndrome (PCOS).
Letrozole was better than Clomiphene as a drug for anovulatory infertility in women with PCOS.
| Basis | Anastrozole | Clomid |
|---|---|---|
| FDA-approved Uses | Breast cancer Endometrial cancer | Ovulatory dysfunction |
| Year of FDA approval | 2000 | 1967 |
| Side effects | Some common side effects of Anastrozole include: Tiredness Low mood Hot flushes Sleeping difficulties | Some common side effects of Azithromycin include: Vomiting Headache Breast discomfort Abnormal vaginal bleeding |
| Avg. Cost | $57-$207 | $6-$133 |
| Others | Generic | Brand |
These comparative advantages of both medications make it necessary to study them in depth.
Read to learn more about the medications and compare them objectively.
What is Anastrozole
Anastrozole is a drug that belongs to the group of drugs called aromatase inhibitors.
It is mainly used to treat hormone receptor-positive breast cancer in women who have gone through menopause.
Anastrozole works by stopping the enzyme aromatase from turning Androgens into Estrogens.
Anastrozole helps slow or stop the growth of hormone-dependent breast cancers by lowering estrogen in the body.
It is usually given as a daily oral medication.
Anastrozole is mainly used to treat breast cancer, but you can also use it off-label for conditions like infertility and Gynecomastia.
Follow the prescribed dosage and consult a healthcare professional for proper guidance and monitoring.
What is Clomid
Clomid (Clomiphene citrate) is a drug used frequently across the field of reproductive medicine.
It is a Selective Estrogen Receptor Modulator (SERM) and is mainly given to women with pregnancy-related problems to make them ovulate.
Clomid works by restricting Estrogen receptors in the hypothalamus.
This makes more Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) come out of the pituitary gland.
This chemical change makes the ovaries release mature eggs, which makes it more likely for conception.
During the menstrual period, most women take Clomid orally for a few days.
It is important to remember that Clomid should only be used under the supervision of a doctor.
Side effects
Both Anastrozole and Clomid have potential side effects.
Arimidex (Anastrozole) may cause vomiting, hot flashes, joint pain, weakness, sore throat, depression, mood changes, nausea, and headache.
Clomid (Clomiphene citrate) may cause headaches, abdominal discomfort, hot flashes, breast tenderness, nausea, and vomiting.
However, as per Fertility and Sterility, Anastrozole is not recommended as a replacement for Clomiphene citrate.
Combination therapy might be a safe and effective alternative for hypoandrogenic subfertile men.
Precautions
There are specific things you need to know before using,
Anastrozole
Always stick to your prescription and avoid change of dosage.
Anastrozole might react with other medications. So inform your doctor if you have other supplements, medications, or herbal products.
Pay regular visits to your doctor for check-ups and monitoring of your progress.
If you develop allergic symptoms after taking Anastrozole, immediately see your doctor.
Consult with your doctor if you are about to conceive, as the drug might harm the fetus or pass into the breast milk.
Keep the medication away from the reach of children. Store it at room temperature and away from heat and moisture.
Clomid
Avoid skipping any dosage and try to finish the entire course of treatment.
Stopping it early might make the symptoms hard to treat.
If you experience stomach discomfort, take the medication after food.
Follow the prescription and take the medication on your menstrual cycle’s 3rd, 4th, or 5th day.
Clomid is associated with multiple pregnancies, so understand the considerations and discuss the risk factors.
Pros and cons
Here is a general overview of the pros and cons of Anastrozole vs. Clomid, which might come in handy.
| Anastrozole | Clomid | |
|---|---|---|
| Pros: | Available as a pill, unlike some other chemotherapy medications Can be taken with or without food Side effects are not as toxic as intravenous chemotherapy medications Available as a lower-cost generic version | Well-tolerated for most people with mild side effects One of the most affordable fertility medications Works well for people with PCOS Available as a tablet, unlike many alternatives |
| Cons: | Weaken your bones Increase your risk of heart disease It can only be used in women who’ve reached menopause Can cause menopausal symptoms as side effects, such as hot flashes and night sweats | Not a good option for long-term use Avoid if you have liver problems or specific thyroid problems Not safe if you have ovarian cysts or enlarged ovaries not caused by PCOS |
Interactions
The working of the medications might change the drug interactions or enhance the risk of side effects.
List all your medicines (prescribed, non-prescribed, and herbal products).
Share the same with your pharmacist and doctor.
Avoid changing, stopping, or starting the dosage of any medicines without your doctor’s approval.
The medications might interact with other drugs, including,
- Tamoxifen
- Estrogen medications (birth control pills, vaginal rings, implants, etc.)
Takeaway
Both Azithromycin and Erythromycin have their benefits and drawbacks as well.
Though both are anti-estrogens, they are prescribed for different purposes.
However, Clomid is generally considered a more convenient and affordable option with fewer side effects.
Ultimately, the choice between the two will significantly depend on individual patient factors, such as,
- The patient’s medical history
- Type of infection, and
- Other medications being taken
Your doctor can help you determine which medication is best for you.
Frequently Asked Questions
Can you take Clomid and Anastrozole together?
You should not combine Clomid with Anastrozole, and you must use it under a physician’s supervision. These drugs work differently and treat distinct problems. Ask your doctor for personalized usage.Â
Is Arimidex better than Clomid?
Arimidex (Anastrozole) and Clomid (Clomiphene citrate) have different uses. Arimidex treats breast cancer, while Clomid treats infertility. An expert will guide you to the best suitable medication for your medical condition.
Is Clomid a good estrogen blocker?
Clomid (Clomiphene citrate) is not primarily intended as an estrogen blocker. It stimulates ovulation and functions as a Selective Estrogen Receptor Modulator (SERM). Clomid can indirectly affect estrogen levels; its mechanism of action differs from dedicated estrogen blockers like Anastrozole.
Why do bodybuilders use Clomid?
Clomid can reduce the impact of performance-enhancing drugs on testosterone production in bodybuilders. It increases the Luteinizing and Follicle-stimulating hormones, restoring testosterone levels and preventing hormonal abnormalities.
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