Dihydrotestosterone (DHT) is an important hormone that shapes the development of the body and overall well-being. 

However, when DHT levels are imbalanced, it can cause problems like hair loss. 

This is where DHT blockers come into the picture. 

Medicines like Finasteride are some popular DHT blockers. Some natural foods can help you too. 

In this article, we will learn the ins and outs of these blockers. 

We will also see what exactly they are, how they work to address different conditions, and their potential side effects.

What is a DHT blocker

A DHT blocker is a treatment option that reduces the levels of DHT in the body or inhibits its effects.

DHT, or Dihydrotestosterone, is a hormone derived from Testosterone.

They are both androgens responsible for the development of male characteristics in the body, like facial hair, deep voice, etc.

Working mechanism

The mechanism of action of DHT blockers to reduce the effects of Dihydrotestosterone can be in two ways. 

Firstly, by blocking the enzyme 5-alpha reductase, which is responsible for converting Testosterone into DHT.

Secondly, by preventing DHT from binding to the androgen receptors in the body.

Fact:
Excess of DHT in the body might lead to:

  • Benign Prostatic Hyperplasia (BPH)
  • Prostate Cancer
  • Androgenic Alopecia (Male Pattern Baldness)
  • Polycystic Ovarian Syndrome (PCOS)

    • Dht blocker uses

    There are several uses of blockers or medications which reduce the effect of DHT.

    Some of them have been discussed below:

    Benign Prostatic Hyperplasia (BPH)

    It is a very common condition in people assigned male at birth who are over the age of 50.

    This condition involves enlargement of the prostate. 

    DHT blockers have been approved by the FDA to treat BPH. 

    They prevent the hormonal changes that cause the prostate to grow, thereby shrinking it. 

    Prostate Cancer

    The growth of prostate cancer cells is dependent upon the presence of hormones, specifically Testosterone and DHT.

    In such cases, DHT blockers are used as hormone therapy in conjunction with other treatments to stop the growth of these hormone-dependent cancer cells.

    Hair loss/ Male Pattern Baldness

    Bald patches on the head due to Male Pattern Baldness
    Male Pattern Baldness

    Excessive DHT can often lead to hair fall as it attaches itself to the receptors on hair follicles on your scalp and causes them to shrink.

    This affects the hair growth cycle and makes your hair thinner and fall out faster.

    A DHT blocker for hair loss, thus, helps balance the hormones by inhibiting the activity of the 5-alpha reductase.

    Recommended Article:
    If you suffer from Male Pattern Baldness and wish to explore the treatment options available, read The Top Treatments for Male Pattern Baldness.

    Acne Vulgaris

    It is an inflammatory disorder of the skin that develops when oil and dead skin cells clog hair follicles.

    DHT blockers have been shown to be an effective treatment for Acne Vulgaris, especially in those displaying the hormonal pattern clinically.

    It is also proven beneficial in women resistant to conventional treatment options.

    Others

    DHT blockers are also used to treat some other conditions which are caused by elevated levels of androgen in the body. 

    These include conditions like PCOS, Hirsutism, etc.

    Research is also going on to better understand the long-term efficacy and safety of using DHT blockers in non-binary people who are transitioning. 

    Available DHT blockers

    DHT blockers are available as medications as well as supplements in the form of tablets, capsules, or topical creams/ serums.

    The tablets and capsules are to be taken orally, while the cream/ serum needs to be applied to the affected area.

    The dosage and frequency of the medication will depend upon the underlying condition being treated, its severity, and other factors.

    Medication

    Medications such as Finasteride and Dutasteride are some commonly known DHT blockers or 5-alpha reductase inhibitors.

    They are both approved by the FDA to treat BPH.

    Finasteride is also FDA-approved to treat Male Pattern Baldness in men.

    They are prescribed off-label by doctors to treat other conditions as well.

    Natural

    Saw Palmetto
    Saw Palmetto seeds

    Natural DHT blockers can also help inhibit the effects of DHT in the body. 

    Food items rich in Zinc, Lycopene, Caffeine, etc., can directly block DHT and are majorly used to treat hair loss.

    The bioactive component of green tea also reduces the synthesis of DHT.

    Herbal supplements such as Saw Palmetto have also been studied to inhibit the enzyme 5-alpha reductase, thereby reducing DHT.

    However, more research is required to conclude the effectiveness of food products as DHT blockers.

    Warning:
    Do not use these medications unless prescribed by your doctor.

    Side effects of DHT blockers

    DHT- blocking medications might cause certain side effects, which include the following:

    • Decreased sex drive
    • Erectile dysfunction
    • Ejaculatory dysfunction
    • Abnormal breast enlargement
    • Anxiety
    • Depression

    However, individual medication might have its own side effects.

    Conclusion

    In conclusion, DHT blockers offer a potential solution for individuals dealing with the effects of DHT on their bodies and hair. 

    They are approved by the FDA to treat Benign Prostatic Hyperplasia (BPH) and, in some cases, hair loss.

    DHT blockers are also known for other off-label uses.

    They are usually available in the form of oral and topical medications, which might cause side effects in some people.

    These side effects include hormonal imbalances, sexual dysfunction, and other related symptoms.

    It is important to seek guidance from qualified healthcare providers to make informed decisions regarding these blockers and their usage. 

    Frequently Asked Questions

    Is Spironolactone a DHT blocker?

    Spironolactone does not belong to the class of medications called DHT blockers or 5-alpha reductase inhibitors. But it works to reduce the levels of Testosterone in the body, which eventually leads to reduced levels of DHT. It also blocks the androgenetic receptors in target tissues.

    Is DHT hair loss reversible?

    DHT-induced hair loss can be reversed to some extent, particularly in the beginning stages. Hair follicles can be restored with appropriate treatment, such as DHT blockers, leading to hair regrowth. However, once hair follicles have become miniaturized or completely dormant; full restoration may not be possible.

    What do DHT blockers do?

    DHT blockers inhibit the production or effects of DHT in the body. They can either reduce the conversion of Testosterone to DHT or block the binding of DHT to androgen receptors. By doing so, they help prevent or mitigate the negative effects of DHT, such as hair loss or prostate enlargement.

    Is blocking DHT bad for you?

    Blocking DHT can have potential side effects and risks, which vary among individuals. Using DHT blockers under medical supervision is important to ensure appropriate dosage and monitoring. Blocking DHT may cause hormonal imbalance or even sexual dysfunction. Discuss the potential side effects with your healthcare provider before using them.

    How long for dht blockers to work?

    The time it takes for DHT blockers to work can vary depending on the individual and the specific treatment. Generally, it may take several months to see noticeable effects. Patience and consistent use as per your doctor’s instructions is important to be able to see results.

    Citations:
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